1159512-26-1

Basic information

• Product Name: 4-Hydroxy-3-nitrophenylsulphur pentafluoride
• Synonyms: 4-Hydroxy-3-nitropentafluorosulphanylbenzene;4-Hydroxy-3-nitrophenylsulphur pentafluoride;2-Nitro-4-(pentafluorothio)phenol, 2-Hydroxy-5-(pentafluorothio)nitrobenzene;2-Nitro-4-(pentafluorosulfanyl)phenol
• CAS NO: 1159512-26-1
• Molecular Formula: C₆H₄F₅NO₃S
• Molecular Weight: 265.157876
• Mol File: 1159512-26-1.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Hydroxy-3-nitrophenylsulphur pentafluoride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Hydroxy-3-nitrophenylsulphur pentafluoride(1159512-26-1)
• EPA Substance Registry System: 4-Hydroxy-3-nitrophenylsulphur pentafluoride(1159512-26-1)

Safety Data

• Hazard Codes: Xi,T
• Hazardous Substances Data: 1159512-26-1(Hazardous Substances Data)

Usage

General Description

4-Hydroxy-3-nitrophenylsulphur pentafluoride, also known as DAST, is a chemical compound commonly used in organic synthesis as a reagent for the conversion of alcohols to fluorides and epoxides to fluorohydrins. It is a versatile and powerful fluorinating agent that is known for its high selectivity and mild reaction conditions. DAST has been utilized in the pharmaceutical industry, as well as in research settings, for the preparation of various fluorinated compounds. However, it is important to handle DAST with caution as it is highly reactive and can be hazardous if not properly handled.

Upstream product

• 774-94-7 4-(pentafluoro-λ⁶-sulfaneyl)phenol 
• 2613-26-5 3-nitrophenylsulfur pentafluoride 

Downstream Products

• 1159512-27-2 3-amino-4-hydroxy(pentafluorosulfanyl)benzene 

Relevant articles and documents

Synthesis of aliphatic sulfur pentafluorides by oxidation of SF5-containing anisole, phenols, and anilines

4-(Pentafluorosulfanyl)catechol, 2-amino-4-(pentafluorosulfanyl)phenol, and 2-amino-5-(pentafluorosulfanyl) phenol undergo oxidation by lead tetraacetate at ambient temperature leading to dearomatization and the formation of SF5-substituted nit

WDR5-MYC INHIBITORS

Substituted N-phenyl sulfonamide compounds inhibit WDR5-MYC interactions, and the compounds and their pharmaceutical compositions are useful for treating disorders and conditions in a subject, such as cancer cell proliferation.

Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein Interaction

The treatment of tumors driven by overexpression or amplification of MYC oncogenes remains a significant challenge in drug discovery. Here, we present a new strategy toward the inhibition of MYC via the disruption of the protein-protein interaction betwee