115953-87-2Relevant academic research and scientific papers
F-substituted-3-β-D-ribofuranosyl-3H-imidazo[4,5-b]pyridines and pharmaceutical compositions thereof
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, (2008/06/13)
This invention discloses a group of compounds of formula (I) STR1 wherein R1 is hydrogen, halo, C1-4 alkyl, C1-4 alkoxy, COOR4 (R4 is H or C1-4 alkyl) or trifluoromethyl; R2, R5 and R6 are the same or different and can be hydrogen, hydroxy, OCOR7 (wherein R7 is hydrogen, C1-4 alkyl, phenyl optionally substituted) or halo; and R3 is hydrogen, COR4, C3-6 cycloalkyl or C1-4 alkyl or alkenyl; R2 may also be a phosphate group and pharmaceutically acceptable salts thereof which have been found to have analgesic activity. In addition, these compounds have antiinflammatory, antipyretic, antihypertensive and vasodilatory activity in varying degrees. Some of these compounds also have antiprotozoal and antiviral properties.
