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Hidiosmin, also known as Hidrosmin, is a semisynthetic drug derived from Diosmin and belongs to the flavonoid family. It is characterized by its yellow to yellow-brown powder form and is recognized for its improved water solubility and bioavailability, which allows for a reduced dosage in comparison to its parent compound, Diosmin. Hidiosmin is known for its effectiveness in treating various venous diseases, particularly Chronic Venous Insufficiency.

115960-14-0

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Basic information
1. Product Name: Hidiosmin
2. Synonyms: 5-O-(beta-Hydroxyethyl)diosmin;4H-1-Benzopyran-4-one,7-[[6-O-(6-deoxy-a-L-Mannopyranosyl)-b-D-glucopyranosyl]oxy]-5-(2-hydroxyethoxy)-2-(3-hydroxy-4-Methoxyphenyl)-;5-(2-hydroxyethoxy)-2-(3-hydroxy-4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[ [(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one;7-[[6-O-(6-Deoxy-a-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-3,5-di-O-hydroxyethyl-2-(3-hydroxy-4-methoxyphenyl)-4H-1-Benzopyran-4-one;7-[[6-O-(6-Deoxy-a-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5-hydroxy-2-(3'-mono-O-hydroxyethyl-4'-methoxyphenyl)-4H-1-Benzopyran-4-one;O-(beta-Hydroxyethyl)diosmin;Hidiosmin
3. CAS NO:115960-14-0
4. Molecular Formula: C30H36O16
5. Molecular Weight: 652.59724
6. EINECS: N/A
7. Product Categories: CITRIMORE
8. Mol File: 115960-14-0.mol
Chemical Properties
1. Melting Point: N/A
2. Boiling Point: 962.7 °C at 760 mmHg
3. Flash Point: 311.1 °C
4. Appearance: /
5. Density: 1.63±0.1 g/cm3 (20 ºC 760 Torr)
6. Vapor Pressure: 0mmHg at 25°C
7. Refractive Index: 1.689
8. Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
9. Solubility: Methanol (Slightly, Sonicated), Water (Slightly)
10. Stability: Hygroscopic
11. CAS DataBase Reference: Hidiosmin(CAS DataBase Reference)
12. NIST Chemistry Reference: Hidiosmin(115960-14-0)
13. EPA Substance Registry System: Hidiosmin(115960-14-0)
Safety Data
1. Hazard Codes: N/A
2. Statements: N/A
3. Safety Statements: N/A
4. WGK Germany:
5. RTECS:
6. HazardClass: N/A
7. PackingGroup: N/A
8. Hazardous Substances Data: 115960-14-0(Hazardous Substances Data)

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115960-14-0 Usage

Uses

Used in Pharmaceutical Industry:
Hidiosmin is used as a therapeutic agent for the treatment of venous diseases, specifically Chronic Venous Insufficiency. It is more effective than Diosmin in treating edema and varicose ulcers due to its enhanced water solubility and bioavailability, which allows for better absorption by the human body and requires a lower dosage for effective treatment.

Check Digit Verification of cas no

The CAS Registry Mumber 115960-14-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,5,9,6 and 0 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 115960-14:
(8*1)+(7*1)+(6*5)+(5*9)+(4*6)+(3*0)+(2*1)+(1*4)=120
120 % 10 = 0
So 115960-14-0 is a valid CAS Registry Number.

InChI:InChI=1/C30H36O16/c1-12-23(34)25(36)27(38)29(43-12)42-11-21-24(35)26(37)28(39)30(46-21)44-14-8-19(41-6-5-31)22-16(33)10-18(45-20(22)9-14)13-3-4-17(40-2)15(32)7-13/h3-4,7-10,12,21,23-32,34-39H,5-6,11H2,1-2H3/t12-,21+,23-,24+,25+,26-,27+,28+,29+,30+/m0/s1

115960-14-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name	5-(2-hydroxyethoxy)-2-(3-hydroxy-4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one

1.2 Other means of identification

Product number	-
Other names	F 117

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:115960-14-0 SDS

115960-14-0Upstream product

115960-14-0Downstream Products

115960-14-0Relevant academic research and scientific papers

Besides sea tune process for the preparation of raw materials

-

Paragraph 0020-0023, (2017/04/26)

The invention provides a process for preparing a hidrosmin bulk drug. The process comprises the following steps: (1) performing a synthesis reaction; (2) decolorizing a reacting liquid; (3) filtering the decolorizing liquid; (4) crystallizing the filterin

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