1159611-68-3

Upstream product

• 1159611-50-3 (R)-ethyl 4-((2R,4S,6S)-6-((S)-4-(tert-butyldiphenylsilyloxy)-2-(4-methoxybenzyloxy)butyl)-4-hydroxytetrahydro-2H-pyran-2-yl)-3-(trimethylsilyloxy)butanoate 
• 108-24-7 acetic anhydride 
• 365404-48-4 5-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-pentanoic acid ethyl ester 
• 1028481-67-5 ethyl (R)-3-(tert-butyldimethylsilyloxy)-4-((2R,6S)-6-((S)-4-(tert-butyldiphenylsilyloxy)-2-(4-methoxybenzyloxy)butyl)-4-methylenetetrahydro-2H-pyran-2-yl)butanoate 
• 1028481-45-9 ethyl (R)-3-(tert-butyldimethylsilyloxy)-5-oxopentanoate 
• 1159611-62-7 ethyl (R)-4-((2S,6R)-6-((S)-4-(tert-butyldiphenylsilyloxy)-2-(4-methoxybenzyloxy)butyl)-4-oxotetrahydro-2H-pyran-2-yl)-3-(trimethylsilyloxy)butanoate 
• 1028481-73-3 ethyl (R)-4-((2R,6S)-6-((S)-4-(tert-butyldiphenylsilyloxy)-2-(4-methoxybenzyloxy)butyl)-4-methylenetetrahydro-2H-pyran-2-yl)-3-(trimethylsilyloxy)butanoate 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 1028481-71-1 ethyl (R)-4-((2R,6S)-6-((S)-4-(tert-butyldiphenylsilyloxy)-2-(4-methoxybenzyloxy)butyl)-4-methylenetetrahydro-2H-pyran-2-yl)-3-hydroxy-butanoate 
• 1028481-69-7 ethyl (R)-4-((2R,6S)-6-((S)-4-(hydroxy)-2-(4-methoxybenzyloxy)butyl)-4-methylenetetrahydro-2H-pyran-2-yl)-3-hydroxy-butanoate 

Downstream Products

• 1159611-51-4 (2S,4R,6S)-2-((S)-4-(tertbutyldiphenylsilyloxy)-2-(4-methoxybenzyloxy)butyl)-6-((S)-2-hydroxy-4-((trimethylsilyl) methyl)pent-4-enyl)tetrahydro-2H-pyran-4-ol 
• 1159611-64-9 (2S,6S)-6-((2R,3R)-3-(benzyloxymethoxy)-2-(tert-butyldimethylsilyloxy)butyl)-2-((E)-4-(6-(((4S)-6-((S)-4-(tert-butyldiphenylsilyloxy)-2-(4-methoxy benzyloxy)butyl)-4-hydroxytetrahydro-2H-pyran-2-yl)methyl)-4-methylenetetrahydro-2H-pyran-2-yl)-2-methylbut-3-en-2-yl)-2-methoxydihydro-2H-pyran-3(4H)-one 
• 1159611-53-6 (2S,6S)-6-((2R,3R)-3-(benzyloxymethoxy)-2-(tert-butyldimethylsilyloxy)butyl)-2-((E)-4-((2R,6S)-6-(((2S,4S,6R)-4-(tert-butyldimethylsilyloxy)-6-((S)-4-(tert-butyldiphenylsilyloxy)-2-(4-methoxybenzyloxy)butyl) tetrahydro-2H-pyran-2-yl)methyl)-4-methylenetetrahydro-2H-pyran-2-yl)-2-methylbut-3-en-2-yl)-2-methoxydihydro-2H-pyran-3(4H)-one 
• 1159611-63-8 (R)-ethyl 4-((2R,4S,6R)-6-((S)-4-(tert-butyldiphenylsilyloxy)-2-(4-methoxybenzyloxy)butyl)-4-(trimethylsilyloxy)tetrahydro-2H-pyran-2-yl)-3-(trimethylsilyloxy)butanoate 

Relevant academic research and scientific papers

BRYOSTATIN ANALOGS AND USE THEREOF AS ANTIVIRAL AGENTS

Described herein are tricyclic macrolactones. The macrolactones have a high binding affinity for PKC. The compounds described herein can be used in a number of therapeutic applications including the treatment or prevention of viral infection. Also described herein are methods for producing macrolactones. The methods permit the high-yield synthesis of macrolactones in a low number of steps and with a high degree of substitution and specificity.

MACROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THEREOF

Described herein are tricyclic macrolactones. The macrolactones have a high binding affinity for PKC. The compounds described herein can be used in a number of therapeutic applications including cancer and Alzheimer's prevention and treatment. The compounds described herein can also treat memory loss. Also described herein are methods for producing macrolactones. The methods permit the high-yield synthesis of macrolactones in fewer steps and with a higher degree of substitution and specificity.

The bryostatin 1 A-ring acetate is not the critical determinant for antagonism of phorbol ester-induced biological responses

The contribution of the A-ring C7 acetate to the function of bryostatin 1 has been investigated through synthesis and biological evaluation of an analogue incorporating this feature into the bryopyran core structure. No enhanced binding affinit