1159694-37-7

Basic information

• Product Name: 5-(4H-1,2,4-triazol-4-yl) benzene-1,3-dicarboxylic acid
• Synonyms: 5-(4H-1,2,4-triazol-4-yl) benzene-1,3-dicarboxylic acid
• CAS NO: 1159694-37-7
• Molecular Weight: 233.183
• Mol File: 1159694-37-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-(4H-1,2,4-triazol-4-yl) benzene-1,3-dicarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4H-1,2,4-triazol-4-yl) benzene-1,3-dicarboxylic acid(1159694-37-7)
• EPA Substance Registry System: 5-(4H-1,2,4-triazol-4-yl) benzene-1,3-dicarboxylic acid(1159694-37-7)

Safety Data

• Hazardous Substances Data: 1159694-37-7(Hazardous Substances Data)

Upstream product

• 99-31-0 5-aminoisophthalic acid 
• 16227-06-8 (1E,N’E)-N’-((dimethylamino)methylene)-N,N-dimethylformohydrazonamide dihydrochloride 
• 16227-06-8 {N'-[(dimethylamino)methylene]-N,N-dimethylhydrazonoformamide dihydrochloride} 

Relevant articles and documents

Isosteric Substitution of 4 H-1,2,4-Triazole by 1 H-1,2,3-Triazole in Isophthalic Derivative Enabled Hydrogel Formation for Controlled Drug Delivery

In this work, we demonstrated that the simple substitution of the 1,2,4-triazole moiety in 5-(4H-1,2,4-triazol-4-yl)isophthalic acid (5-TIA) by the 1H-1,2,3-triazol-5-yl unit enables the preparation of a hydrogelator (click-TIA). In sharp contrast to 5-TIA, its isostere click-TIA undergoes self-assembly in water upon sonication, leading to the formation of stable supramolecular viscoelastic hydrogels with a critical gelation concentration of 6 g/L. Hydrogels made of click-TIA as well as hybrid hydrogels made of the mixture click-TIA + 5-TIA (molar ratio 1:0.2) were used to compare different properties of the materials (i.e., rheological properties, thermal properties, mechanical stability, morphology). In terms of toxicity, neither click-TIA nor 5-TIA showed cytotoxic effects on cellular viability of HeLa cells up to 2.3 × 10-3 g/L when compared to untreated cells incubated with DMSO. Furthermore, the hydrogels were used for the encapsulation and in vitro controlled release of oxytetracycline that followed first-order kinetics. For the hydrogel made of click-TIA, a maximum drug release of ～60% was reached after ～8 h within a pH range between 6.5 and 10. However, the release rate was reduced to approximately half of its value at pH values between 1.2 and 5.0, whereas the use of hybrid hydrogels made of click-TIA + 5-TIA allowed to reduce the original rate at pH ≤ 6.5.

Template induced structural isomerism and enhancement of porosity in manganese(II) based metal-organic frameworks (Mn-MOFs)

Three new metal-organic framework isomers have been synthesized by using the organic linker 5-triazole isophthalic acid and Mn(NO3) 2·xH2O. Structural conversions from non-porous to porous MOFs due to the template effect have been observed. The cross-sectional pore apertures of the resulting Mn-MOFs are comparable to the molecular dimensions of the template (pyrazine and 4,4′-bipyridine). The periodic increased porosity in Mn-MOFs depending on the size of the template used has been further confirmed by the CO2 adsorption isotherms.