1159707-92-2Relevant academic research and scientific papers
Synthesis and evaluation of the cytotoxicities of neoflavenes
Li, Sie-Rong,Chen, Hsing-Ming,Chen, Po-Yuan,Tsai, Jui-Chi,Chen, Liang-Yeu,Wang, Eng-Chi,Huang, Yi-Ting,Wei, Yun-Chen,Lu, Pei-Jung
experimental part, p. 923 - 932 (2009/12/08)
The synthesis of neoflavene and neoflavenes with methoxy substituents at different positions are described. As starting materials, various salicylaldehydes were run through sequential reactions such as O-allylation, Grignard reaction, oxidation, Wittig reaction, and ring-closing metathesis to yield the target neoflavenes in good yield. Among the prepared neoflavenes, 7-methoxy-4′-methoxyneoflavene (6e) and 8-methoxy-4′- methoxyneoflavene (6f) exhibiting potential cell toxicities against various cells were disclosed. In particular, 6f which exhibited an IC50 value of 6.5 ± 2.0 and 5.1 ± 1.1 μM against gastric carcinoma and lung carcinoma cells in vitro was found, respectively. Meanwhile, the structure and activity relationship of our synthesized neoflavenes is further discussed briefly.
