115972-68-4Relevant academic research and scientific papers
NEW SUBSTITUTED CYANOINDOLINE DERIVATIVES AS NIK INHIBITORS
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Page/Page column 343; 344, (2017/08/20)
The present invention relates to pharmaceutical agents of formula (I) useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of NF- KB-inducing kinase (NIK - also known as MAP3K14) useful for treating diseases such as cancer, inflammatory disorders, metabolic disorders and autoimmune disorders. The invention is also directed to pharmaceutical compositions comprising such compounds, and to the use of such compounds or pharmaceutical compositions for the prevention or treatment of diseases such as cancer, inflammatory disorders, metabolic disorders including obesity and diabetes, and autoimmune disorders.
Organocatalytic regiospecific synthesis of 1H-indene-2-carbaldehyde derivatives: suppression of cycloolefin isomerisation by employing sterically demanding catalysts
Mao, Hui,Kim, Dong Wan,Shin, Hun Yi,Song, Choong Eui,Yang, Jung Woon
supporting information, p. 1355 - 1362 (2017/02/15)
The regiospecific synthesis of 1H-indene-2-carbaldehyde derivatives was achieved through transition-metal-free, reductive cyclisation of ortho-formyl trans-cinnamaldehydes with Hantzsch ester in the presence of an aminocatalyst. In particular, cycloolefin isomerisation of the resulting products could be inhibited efficiently by the introduction of a sterically demanding stereo-defined aminocatalyst.
Phenylurea herbicides
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, (2008/06/13)
A compounds of the Formula I wherein R1 and R2 each independently is a hydrogen atom, cyclopropyl, or alkyl or alkoxy containing 1 to 5 carbon atoms; R3 is hydrogen or alkyl or alkoxy containing 1 to 3 carbon atoms; X is 0 or S; Y is hydrogen, alkyl containing 1 to 4 carbon atoms, fluorine, chlorine or bromine; Z is hydrogen or fluorine; and n is 1 or 2, are useful as herbicides.
