115975-33-2

Basic information

• Product Name: 2,4-Bis(trifluoroacetyl)-1-(N,N-dimethylamino)naphthalene
• Synonyms: 2,4-Bis(trifluoroacetyl)-1-(N,N-dimethylamino)naphthalene;2,4-Bis(trifluoroacetyl)-N,N-dimethylnaphth-1ylamine
• CAS NO: 115975-33-2
• Molecular Formula: C₁₆H₁₁F₆NO₂
• Molecular Weight: 363.26
• Mol File: 115975-33-2.mol
• Article Data: 2

Chemical Properties

• Melting Point: 87-88 °C
• Boiling Point: 408.6°Cat760mmHg
• Flash Point: 200.9°C
• Appearance: /
• Density: 1.411g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.529
• PKA: -2.67±0.40(Predicted)
• CAS DataBase Reference: 2,4-Bis(trifluoroacetyl)-1-(N,N-dimethylamino)naphthalene(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Bis(trifluoroacetyl)-1-(N,N-dimethylamino)naphthalene(115975-33-2)
• EPA Substance Registry System: 2,4-Bis(trifluoroacetyl)-1-(N,N-dimethylamino)naphthalene(115975-33-2)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 115975-33-2(Hazardous Substances Data)

Usage

General Description

2,4-Bis(trifluoroacetyl)-1-(N,N-dimethylamino)naphthalene is a compound with a chemical formula C20H15F6NO2. It is a fluorescent dye and is used as a reagent for the determination of amino acids and peptides through fluorescence detection. The compound is known for its strong fluorescence and is commonly used in the field of biochemistry and molecular biology for labeling and detection purposes. It is also used as a molecular probe for studying protein-protein interactions and has potential applications in medical diagnostics and drug development. Due to its unique chemical structure and properties, 2,4-Bis(trifluoroacetyl)-1-(N,N-dimethylamino)naphthalene has proven to be a valuable tool in various research and industrial applications.

InChI:InChI=1/C16H11F6NO2/c1-23(2)12-9-6-4-3-5-8(9)10(13(24)15(17,18)19)7-11(12)14(25)16(20,21)22/h3-7H,1-2H3

Upstream product

• 86-56-6 N,N-dimethyl-1-naphthalenamine 
• 407-25-0 trifluoroacetic anhydride 

Downstream Products

• 130158-18-8 1-[1-(4-Chloro-phenylamino)-4-(2,2,2-trifluoro-acetyl)-naphthalen-2-yl]-2,2,2-trifluoro-ethanone 
• 115975-40-1 N-(4-methoxyphenyl)-2,4-bis(trifluoroacetyl)-1-naphthylamine 
• 142991-54-6 2,4-bis(trifluoroacetyl)-1-(4-methoxyphenoxy)naphthalene 
• 126045-93-0 3-Hydroxy-2-phenyl-5-(2,2,2-trifluoro-acetyl)-3-trifluoromethyl-2,3-dihydro-1H-benzo[g]indole-2-carboxylic acid ethyl ester 
• 115975-39-8 1-[1-Benzylamino-4-(2,2,2-trifluoro-acetyl)-naphthalen-2-yl]-2,2,2-trifluoro-ethanone 
• 129602-66-0 2,2,2-trifluoro-1-(2-phenyl-3-(trifluoromethyl)-2H-benzo[g]indazol-5-yl)ethanone 
• 142991-52-4 1-[1-(4-Chloro-phenylsulfanyl)-4-(2,2,2-trifluoro-acetyl)-naphthalen-2-yl]-2,2,2-trifluoro-ethanone 
• 127053-13-8 2,4-bis(trifluoroacetyl)-1-naphthyl benzyl sulfide 
• 143015-28-5 2,2,2-Trifluoro-1-[1-(4-methoxy-phenylsulfanyl)-4-(2,2,2-trifluoro-acetyl)-naphthalen-2-yl]-ethanone 
• 127053-15-0 2,4-bis(trifluoroacetyl)-1-(4-methylphenylthio)naphthalene 
• 130158-17-7 2,2,2-Trifluoro-1-[1-phenylamino-4-(2,2,2-trifluoro-acetyl)-naphthalen-2-yl]-ethanone 
• 143015-29-6 2,2,2-Trifluoro-1-[1-phenylsulfanyl-4-(2,2,2-trifluoro-acetyl)-naphthalen-2-yl]-ethanone 

Relevant articles and documents

A Facile and Convenient Synthesis of Fluorine-Containing Naphthoxazines by Novel Cyclization of N,N-Dialkyl-2,4-bis(trifluoroacetyl)-1-naphthylamines

N,N-Dialkyl-2,4-bis(trifluoroacetyl)-1-naphthylamines (1a-j) underwent acid catalyzed cyclization by trifluoroacetic acid or silica gel to give naphthoxazines (2a-j) in excellent yields.Naphthylamines (1b,d,e,h-j) were found to perform this type of cyclization easily in refluxing butyronitrile or acetonitrile even in the absence of acids.Remarkably high regioselectivities were exhibited in the cyclization of unsymmetrically N,N-dialkyl-substituted naphthylamines (1g-j) and the corresponding naphthoxazines (2g-j) were obtained in high yields.