115975-33-2

Usage

Uses

Used in Biochemistry and Molecular Biology:
2,4-Bis(trifluoroacetyl)-1-(N,N-dimethylamino)naphthalene is used as a reagent for the determination of amino acids and peptides, leveraging its strong fluorescence for detection purposes.
Used as a Molecular Probe:
In the field of biochemistry and molecular biology, 2,4-Bis(trifluoroacetyl)-1-(N,N-dimethylamino)naphthalene is used as a molecular probe to study protein-protein interactions, providing insights into complex biological processes.
Used in Medical Diagnostics:
2,4-Bis(trifluoroacetyl)-1-(N,N-dimethylamino)naphthalene has potential applications in medical diagnostics, where its fluorescent properties can be employed for the detection and monitoring of various diseases and conditions.
Used in Drug Development:
2,4-Bis(trifluoroacetyl)-1-(N,N-dimethylamino)naphthalene is also utilized in drug development, where it can aid in the discovery and optimization of new therapeutic agents by providing a means to track and analyze drug-target interactions.
Used in Research and Industrial Applications:
Due to its unique chemical structure and properties, 2,4-Bis(trifluoroacetyl)-1-(N,N-dimethylamino)naphthalene is a valuable tool in a wide range of research and industrial applications, including the development of new materials and technologies that rely on fluorescence-based detection methods.

InChI:InChI=1/C16H11F6NO2/c1-23(2)12-9-6-4-3-5-8(9)10(13(24)15(17,18)19)7-11(12)14(25)16(20,21)22/h3-7H,1-2H3

Upstream product

• 86-56-6 N,N-dimethyl-1-naphthalenamine 
• 407-25-0 trifluoroacetic anhydride 

Downstream Products

• 127053-19-4 2,2,2-Trifluoro-1-[4-(2-phenoxy-ethoxy)-3-(2,2,2-trifluoro-acetyl)-naphthalen-1-yl]-ethanone 
• 129602-67-1 2,2,2-Trifluoro-1-[2-(4-nitro-phenyl)-3-trifluoromethyl-2H-benzo[g]indazol-5-yl]-ethanone 
• 130158-18-8 1-[1-(4-Chloro-phenylamino)-4-(2,2,2-trifluoro-acetyl)-naphthalen-2-yl]-2,2,2-trifluoro-ethanone 
• 142991-54-6 2,4-bis(trifluoroacetyl)-1-(4-methoxyphenoxy)naphthalene 
• 127053-15-0 2,4-bis(trifluoroacetyl)-1-(4-methylphenylthio)naphthalene 
• 143015-28-5 2,2,2-Trifluoro-1-[1-(4-methoxy-phenylsulfanyl)-4-(2,2,2-trifluoro-acetyl)-naphthalen-2-yl]-ethanone 
• 126045-93-0 3-Hydroxy-2-phenyl-5-(2,2,2-trifluoro-acetyl)-3-trifluoromethyl-2,3-dihydro-1H-benzo[g]indole-2-carboxylic acid ethyl ester 
• 115975-39-8 1-[1-Benzylamino-4-(2,2,2-trifluoro-acetyl)-naphthalen-2-yl]-2,2,2-trifluoro-ethanone 
• 129602-66-0 2,2,2-trifluoro-1-(2-phenyl-3-(trifluoromethyl)-2H-benzo[g]indazol-5-yl)ethanone 
• 142991-52-4 1-[1-(4-Chloro-phenylsulfanyl)-4-(2,2,2-trifluoro-acetyl)-naphthalen-2-yl]-2,2,2-trifluoro-ethanone 
• 127053-13-8 2,4-bis(trifluoroacetyl)-1-naphthyl benzyl sulfide 
• 130158-17-7 2,2,2-Trifluoro-1-[1-phenylamino-4-(2,2,2-trifluoro-acetyl)-naphthalen-2-yl]-ethanone 

Relevant academic research and scientific papers

A Facile and Convenient Synthesis of Fluorine-Containing Naphthoxazines by Novel Cyclization of N,N-Dialkyl-2,4-bis(trifluoroacetyl)-1-naphthylamines

N,N-Dialkyl-2,4-bis(trifluoroacetyl)-1-naphthylamines (1a-j) underwent acid catalyzed cyclization by trifluoroacetic acid or silica gel to give naphthoxazines (2a-j) in excellent yields.Naphthylamines (1b,d,e,h-j) were found to perform this type of cyclization easily in refluxing butyronitrile or acetonitrile even in the absence of acids.Remarkably high regioselectivities were exhibited in the cyclization of unsymmetrically N,N-dialkyl-substituted naphthylamines (1g-j) and the corresponding naphthoxazines (2g-j) were obtained in high yields.

NUCLEOPHILIC NITROGEN-NITROGEN EXCHANGE REACTION AT AROMATIC CARBON ATOMS - REACTION OF N,N-DIMETHYL-2,4-BISTRIFLUOROACETYL-1-NAPHTHYLAMINE WITH VARIOUS AMINES

N,N-Dimethyl-1-naphthylamine reacted easily with trifluoroacetic anhydride to give the title compound 2 quantitatively.Aromatic nucleophilic substitution reaction of 2 with various amines proceeded readily under mild conditions to give the corresponding n