1159909-00-8Relevant academic research and scientific papers
Inhibitors of hepatitis C virus NS3/4A: α-Ketoamide based macrocyclic inhibitors
Avolio, Salvatore,Robertson, Keith,Hernando, Jose Ignacio Martin,DiMuzio, Jillian,Summa, Vincenzo
, p. 2295 - 2298 (2009)
A novel series of hepatitis C virus (HCV) NS3/4A protease inhibitors bearing a P2-P4 macrocycle and a P1-P1′ α-ketoamide serine trap is reported. The NS3 protease, which is essential for viral replication, is considered one of the most attractive targets
