1159983-30-8 Usage
Uses
Used in Organic Synthesis:
2-(4-AMINO-1-(TERT-BUTOXYCARBONYL)PIPERIDIN-4-YL)ACETIC ACID is used as an organic synthesis intermediate for the creation of various complex organic molecules. Its unique structure allows it to be a versatile building block in the synthesis of a wide range of compounds.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 2-(4-AMINO-1-(TERT-BUTOXYCARBONYL)PIPERIDIN-4-YL)ACETIC ACID is used as a pharmaceutical intermediate. It plays a crucial role in the development of new drugs, contributing to the synthesis of active pharmaceutical ingredients (APIs) that can be used in the formulation of medications.
Used in Laboratory Research and Development:
2-(4-AMINO-1-(TERT-BUTOXYCARBONYL)PIPERIDIN-4-YL)ACETIC ACID is employed as a research tool in laboratories. Scientists use it to study the properties and reactions of various organic and pharmaceutical compounds, aiding in the advancement of scientific knowledge and the development of innovative products.
Used in Chemical Production Process:
2-(4-AMINO-1-(TERT-BUTOXYCARBONYL)PIPERIDIN-4-YL)ACETIC ACID is also utilized in the chemical production process, where it is involved in the large-scale synthesis of various chemicals. Its presence in this process ensures the efficient and cost-effective production of a wide array of chemical products.
Synthesis
A mixture of 4-oxo-piperidine- 1 -carboxylic acid tert-butyl ester (3.5 g, 17.55 mmol) (Sigma- Aldrich), malonic acid (2.0 g, 19.30 mmol) and ammonium acetate (3.1 g, 40.36 mmol) in n-BuOH was refluxed for 3 h. After cooled, white solid was collected, rinsed with EtOAc and dried in vacuo to provide the title compound 1.61 g (6.2 mmol) in 36% yield.
Check Digit Verification of cas no
The CAS Registry Mumber 1159983-30-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,5,9,9,8 and 3 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1159983-30:
(9*1)+(8*1)+(7*5)+(6*9)+(5*9)+(4*8)+(3*3)+(2*3)+(1*0)=198
198 % 10 = 8
So 1159983-30-8 is a valid CAS Registry Number.
1159983-30-8Relevant articles and documents
Inhibition of Invasion in Pancreatic Cancer Cells by Conjugate of EPA with β3,3-Pip-OH via PI3K/Akt/NF-kB Pathway
Amin, Hina,Wani, Naiem Ahmad,Farooq, Saleem,Nayak, Debasis,Chakraborty, Souneek,Shankar, Sudha,Rasool, Reyaz Ur,Koul, Surinder,Goswami, Anindya,Rai, Rajkishor
, p. 1071 - 1074 (2015)
The present work describes the anti-invasive effect of conjugate BC06, a novel conjugate of EPA, (2E,4E)-4-(benzo[d][1,3]dioxol-5-ylmethylene) hex-2-enoic acid with β,β-disubstituted-β-amino acid, β3,3-Pip-OH (2-(4-aminopiperidin-4-yl)acetic acid), in human pancreatic carcinoma. The conjugate BC06 inhibited invasion and migration of PANC-1 cells in wound healing, matrigel invasion, and gelatin degradation assays. Apart from suppressing PI3K/Akt/NF-kB signaling, which is involved in the up-regulation of matrix metalloproteinases, our study also demonstrated that dose-dependent treatment of BC06 results in the upregulation of TIMP-1 and E-cadherin expression. Further, BC06 was found to be inhibiting the metastatic ability of PANC-1 cells by reducing MMP-2 and MMP-9 expression. These findings suggest that EPA conjugate with β3,3-Pip-OH, BC06, may be used as an anti-invasive agent against human pancreatic carcinoma.
4 -HYDROXY- ISOQUINOLINE COMPOUNDS AS HIF HYDROXYLASE INHIBITORS
-
Paragraph 0373, (2013/09/26)
The present invention relates to novel compounds of formula (I), and compositions capable of inhibiting PHD1 enzyme activity selectively over other isoforms, for example, PHD2 and/or PHD3 enzymes. The invention also relates to compounds of formula (I) for use in disorders such as muscle degeneration, colitis, IBD, and certain ischemias.
