1159996-70-9Relevant academic research and scientific papers
Synthesis of enantiopure (R,R)- and (S,S)-cis-2,3-propanoprolines
Kopylova, Natalia A.,Grygorenko, Oleksandr O.,Komarov, Igor V.,Groth, Ulrich
, p. 2868 - 2871 (2011/03/19)
A novel approach to the synthesis of an enantiopure bicyclic proline analogue, hexahydrocyclopenta[b]pyrrole-6a(1H)-carboxylic acid ('2,3-propanoproline'), has been developed. The method relied on tandem Strecker-nucleophilic cyclization reaction of 2-(2-
Synthesis of Boc-protected bicycloproline
Ranatunga, Sujeewa,Valle, Juan R. Del
supporting information; experimental part, p. 2464 - 2466 (2009/08/09)
The synthesis of a highly constrained quaternary carbocyclic α-amino acid, (+)-N-Boc-bicycloproline, has been achieved starting from sodium cyclopentadienylide. Key steps include a rhodium-catalyzed nitrenoid C-H insertion to install the tert-alkylamine a
