Cas 1160004-82-9,tert-butyl (5aS,8aS)-3-(4-(trifluoromethyl)phenyl)-5a,6,8,8a-tetrahydro-4H,7H-pyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine-7-carboxylate

1160004-82-9

Post Buying Request

Basic information

Product Name: tert-butyl (5aS,8aS)-3-(4-(trifluoromethyl)phenyl)-5a,6,8,8a-tetrahydro-4H,7H-pyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine-7-carboxylate
Synonyms:
CAS NO:1160004-82-9
Molecular Formula:
Molecular Weight: 410.396
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: tert-butyl (5aS,8aS)-3-(4-(trifluoromethyl)phenyl)-5a,6,8,8a-tetrahydro-4H,7H-pyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine-7-carboxylate(CAS DataBase Reference)
NIST Chemistry Reference: tert-butyl (5aS,8aS)-3-(4-(trifluoromethyl)phenyl)-5a,6,8,8a-tetrahydro-4H,7H-pyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine-7-carboxylate(1160004-82-9)
EPA Substance Registry System: tert-butyl (5aS,8aS)-3-(4-(trifluoromethyl)phenyl)-5a,6,8,8a-tetrahydro-4H,7H-pyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine-7-carboxylate(1160004-82-9)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 1160004-82-9(Hazardous Substances Data)

Suppliers
Usage
Upstream product
Downstream Products
Article

1160004-82-9 Suppliers

Recommended suppliers

1160004-82-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1160004-82-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,6,0,0,0 and 4 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1160004-82:
(9*1)+(8*1)+(7*6)+(6*0)+(5*0)+(4*0)+(3*4)+(2*8)+(1*2)=89
89 % 10 = 9
So 1160004-82-9 is a valid CAS Registry Number.

1160004-82-9Upstream product

214360-65-3 4-trifluoromethylphenylboronic acid pinacol ester

1160004-82-9Downstream Products

1160004-82-9Relevant academic research and scientific papers

Tricyclic Triazoles as σ1Receptor Antagonists for Treating Pain

Díaz, José Luis,Cuevas, Félix,Oliva, Ana I.,Font, Daniel,Sarmentero, M. ángeles,álvarez-Bercedo, Paula,López-Valbuena, José M.,Pericàs, Miquel A.,Enrech, Raquel,Montero, Ana,Yeste, Sandra,Vidal-Torres, Alba,álvarez, Inés,Pérez, Pilar,Cendán, Cruz Miguel,Cobos, Enrique J.,Vela, José Miguel,Almansa, Carmen

, p. 5157 - 5170 (2021)

The synthesis and pharmacological activity of a new series of 5a,7,8,8a-tetrahydro-4H,6H-pyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine derivatives as potent sigma-1 receptor (σ1R) ligands are reported. A lead optimization program aimed at improving the aqueous solubility of parent racemic nonpolar derivatives led to the identification of several σ1R antagonists with a good absorption, distribution, metabolism, and excretion in vitro profile, no off-target affinities, and characterized by a low basic pKa (around 5) that correlates with high exposure levels in rodents. Two compounds displaying a differential brain-to-plasma ratio distribution profile, 12lR and 12qS, exhibited a good analgesic profile and were selected as preclinical candidates for the treatment of pain.

Tricyclic triazolic compounds

-

Page/Page column 50, (2009/07/10)

The present invention relates to new tricyclic triazolic compounds having a high affinity for sigma-1 receptor as well as to the process for the preparation thereof, to composition comprising them and to their use as medicaments according to compounds of

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 1160004-82-9