1160052-52-7Relevant academic research and scientific papers
Synthesis of α,β-diamino acid derivatives via asymmetric Mannich reactions of glycine imino esters catalyzed by a chiral phosphoramidite·silver complex Dedicated to the memory of Prof. Ekkehard Winterfeldt
Cayuelas, Alberto,Serrano, Loane,Njera, Carmen,Sansano, Jos M.
, p. 1647 - 1653 (2015/03/03)
AgOTf·phosphoramidite complexes efficiently catalyze the enantioselective Mannich-type reaction between benzophenone-imine glycine methyl ester and N-tosyl aldimines in the absence of a base. The corresponding syn-adducts, which are the direct precursors of α,β-diamino acids, are obtained with moderate to good syn-diastereoselectivities (up to 9:1) and high enantioselectivities (up to 99% ee).
Ag/ThioClickFerrophos-catalyzed enantioselective mannich reaction and amination of glycine schiff base
Imae, Kazumi,Shimizu, Kenta,Ogata, Kenichi,Fukuzawa, Shin-Ichi
experimental part, p. 3604 - 3608 (2011/06/27)
The AgOAc/ThioClickFerrophos complex catalyzed the asymmetric Mannich reaction of glycine Schiff base with N-tosylimines effectively to give a mixture of syn and anti adducts (syn/anti = 60/40-70/30) at high yields with high enantioselectivities (up to 98% ee). The complex also catalyzed the asymmetric amination of glycine Schiff base with di-tert-butyl azodicarboxylate with high enantioselectivity.
Catalytic asymmetric mannich reaction of glycine derivatives with N-tosylimines using copper(I)/TF-biphamphos complex
Liang, Gang,Tong, Min-Chao,Tao, Haiyan,Wang, Chun-Jiang
supporting information; experimental part, p. 1851 - 1855 (2010/10/21)
The direct asymmetric Mannich reaction of glycine Schiff bases with N-tosylimines has been developed with the tetrakis(acetonitrile)copper(I) tetrafluoroborate [Cu(CH3CN)4BF4]/TF-Bipham- Phos complex. This catalytic system performs well over a broad range of substrates, furnishing anti-adducts of various α,β-diamino acid esters in good yields with up to 94:6 diastereoselectivity and 97% enantioselectivity.
A N,N′-dioxide-copper(II) complex as an efficient catalyst for the enantioselective and diastereoselective mannich-type reaction of glycine schiff bases with aldimines
Shang, Deju,Liu, Yanling,Zhou, Xin,Liu, Xiaohua,Feng, Xiaoming
supporting information; experimental part, p. 3678 - 3681 (2010/01/14)
A study was conducted to demonstrate the efficient Mannich-type reaction of the glycine Schiff base 1 with aldimines using N'N-dioxide-copper(II) acetate complexes as catalysts. The efficient reaction helped in obtaining significant enantioselectivity and
