1160052-60-7Relevant academic research and scientific papers
Synthesis of α,β-diamino acid derivatives via asymmetric Mannich reactions of glycine imino esters catalyzed by a chiral phosphoramidite·silver complex Dedicated to the memory of Prof. Ekkehard Winterfeldt
Cayuelas, Alberto,Serrano, Loane,Njera, Carmen,Sansano, Jos M.
, p. 1647 - 1653 (2015/03/03)
AgOTf·phosphoramidite complexes efficiently catalyze the enantioselective Mannich-type reaction between benzophenone-imine glycine methyl ester and N-tosyl aldimines in the absence of a base. The corresponding syn-adducts, which are the direct precursors of α,β-diamino acids, are obtained with moderate to good syn-diastereoselectivities (up to 9:1) and high enantioselectivities (up to 99% ee).
Syn-selective asymmetric mannich reaction of sulfonyl imines with iminoesters catalyzed by the N,N,N-tridentate bis(imidazolidine)pyridine (PyBidine)-Cu(OTf)2 complex
Arai, Takayoshi,Mishiro, Asami,Matsumura, Eri,Awata, Atsuko,Shirasugi, Mayu
supporting information, p. 11219 - 11222 (2012/11/07)
Chiral ligand: The [PyBidine-Cu(OTf)2] (Tf= trifluoromethanesulfonate) complex catalyzed the asymmetric Mannich reaction of sulfonyl imines and iminoesters to give the products in a high syn-selective manner. For both 4-toluene (Ts)- and 4-nitrophenylsulfonyl (Ns)-imines, the syn-adducts were obtained in up to 99 % ee (see scheme). Copyright
A N,N′-dioxide-copper(II) complex as an efficient catalyst for the enantioselective and diastereoselective mannich-type reaction of glycine schiff bases with aldimines
Shang, Deju,Liu, Yanling,Zhou, Xin,Liu, Xiaohua,Feng, Xiaoming
supporting information; experimental part, p. 3678 - 3681 (2010/01/14)
A study was conducted to demonstrate the efficient Mannich-type reaction of the glycine Schiff base 1 with aldimines using N'N-dioxide-copper(II) acetate complexes as catalysts. The efficient reaction helped in obtaining significant enantioselectivity and
