1160112-06-0Relevant articles and documents
Cobalt-catalyzed arylzincation of alkynes
Murakami, Kei,Yorimitsu, Hideki,Oshima, Koichiro
, p. 2373 - 2375 (2009)
Cobalt(II) bromide catalyzes arylzincation of alkynes with arylzinc iodide·lithium chloride complexes in acetonitrile. The scope of the arylzincation is wide enough to use unfunctionalized alkynes, such as 6-dodecyne, as well as arylacetylenes. The inherent functional group compatibility of arylzinc reagents allows preparation of various functionalized styrene derivatives. The reaction is applicable to the efficient and stereoselective synthesis of a synthetic estrogen and its derivative.