1160168-52-4Relevant academic research and scientific papers
Novel synthesis of pyrano[2,3-d]thiazole, thiazolo[3,2-a]pyridine, and pyrazolo [3′,4′:4,5] thiazolo[3,2-a]pyridine derivatives
El-Hag Ali,Abd El-Rahman,Helal,El-Gaby
experimental part, p. 3023 - 3036 (2009/09/25)
Cyclocondensation of 2-cyanomethyl-4-thiazolidinone (1) with tetracyanoethylene (2) furnished pyrano[2,3-d]thiazole derivative (4). Benzo[e]pyrano[2,3-d]thiazole derivative (6) was obtained by cyclization of compound (1) with salicylaldehyde. In a similar manner, condensation of compound (1) with 2-hydroxy-1-naphthaldehyde in refluxing ethanol yielded naphtho[e]pyrano[2,3-d]thiazole derivative (7). Interaction of compound (9) with benzylidenemalononitriles (10) (1:1 molar ratio) at reflux temperature in ethanol in the presence of piperidine afforded thiazolo[3,2-a]pyridines (12a-c). Treatment of compound (12a) with hydrazines furnished pyrazolo[3′, 4′:4,5] thiazolo[3,2-a]pyridines (14a,b). The reaction of compound (1) with benzyli-denecyanoacetate (16) yielded 5-hydroxythiazolo[3,2-a]pyridine derivative (21). Cyclization of bis(thiazolinone) (23) with benzylidenemalononitriles (10) produced bis(thiazolopyridine) derivatives (25a,b). Copyright Taylor & Francis Group, LLC.
