1160218-00-7Relevant articles and documents
Methyl mercapturate synthesis: An efficient, convenient and simple method
Cossec, Benoit,Cosnier, Frederic,Burgart, Manuella
experimental part, p. 2394 - 2407 (2009/04/11)
A safe and simple method for methyl S-arylmercapturate synthesis is described. Thirteen such compounds, to be used afterwards in metabolism studies, have been obtained with yields ranging from 71 to 99.6%. These compounds were obtained using a sulfa-Michael addition and synthesized by adding the corresponding thiophenols to a mixture composed of methyl 2-acetamidoacrylate (MAA), potassium carbonate and a phase transfer catalyst, Aliquat 336. MAA, the initial synthon, was itself isolated in quasi quantitative yield following a fully described synthesis.
