1160247-09-5Relevant articles and documents
Tert-butyl -8 - oxygen asia base - 2, 6, 9 - triazaspiro [4.5] decane -2 - formic acid ester synthesis method (by machine translation)
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Paragraph 0007; 0008, (2019/04/04)
The invention relates to one kind of uncle butyl 8 - oxygen asia base - 2, 6, 9 - triazaspiro [4.5] decane - 2 - formic acid ester synthesis method, mainly solves the industrial synthesis method not suitable for the technical problem. The invention is divided into 2 step, 1st step, in which is dissolved with the compound 1 and amino acetic acid ethyl ester hydrochloride in methanol solution of triethylamine is added, then the reaction solution is added to the four isopropoxy [...] in, the completion of the dropping, the mixing system 25 °C reaction 12 hours. Then the trimethyl cyanogen silane in 25 °C into the reaction system, then 25 °C reaction 12 hours, post-processed to obtain compound 2. 2nd step, in methanol solution and adding compound 2, nickel, and ammonia, hydrogenation reaction to obtain the final compound. (by machine translation)
