1160247-92-6Relevant articles and documents
Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins
Bridges, Thomas M.,Marlo, Joy E.,Niswender, Colleen M.,Jones, Carrie K.,Jadhav, Satyawan B.,Gentry, Patrick R.,Plumley, Hyekyung C.,Weaver, C. David,Conn, P. Jeffrey,Lindsley, Craig W.
supporting information; experimental part, p. 3445 - 3448 (2010/04/02)
This report describes the discovery and initial characterization of the first positive allosteric modulator of muscarinic acetylcholine receptor subtype 5 (mAChR5 or M5). Functional HTS, identified VU0119498, which displayed micromolar potencies for poten