1160264-60-7

Basic information

• Product Name: 2-(3-methoxyphenyl)quinoline-4-carbonyl chloride
• Synonyms: 2-(3-methoxyphenyl)quinoline-4-carbonyl chloride;4-quinolinecarbonyl chloride, 2-(3-methoxyphenyl)-
• CAS NO: 1160264-60-7
• Molecular Formula: C₁₇H₁₂ClNO₂
• Molecular Weight: 297.73568
• Mol File: 1160264-60-7.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(3-methoxyphenyl)quinoline-4-carbonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-methoxyphenyl)quinoline-4-carbonyl chloride(1160264-60-7)
• EPA Substance Registry System: 2-(3-methoxyphenyl)quinoline-4-carbonyl chloride(1160264-60-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 1160264-60-7(Hazardous Substances Data)

Upstream product

• 159782-19-1 2-(3-methoxyphenyl)quinoline-4-carboxylic acid 
• 42366-35-8 hydroxyimino-N-phenylacetamide 
• 91-56-5 indole-2,3-dione 
• 62-53-3 aniline 

Relevant articles and documents

Design, synthesis and antitumour activity of bisquinoline derivatives connected by 4-oxy-3-fluoroaniline moiety

A series of novel bisquinoline derivatives connected by a 4-oxy-3-fluoroaniline moiety were synthesized and evaluated for their in vitro antitumour activities against a panel of five cancer cell lines (H460, HT-29, MKN-45, U87MG, and SMMC-7721). Most of compounds tested showed a potent activity and high selectivity towards the H460 and MKN-45 cell lines. Among the compounds tested, six (15d, 15e, 15m, 15n, 16a, and 16i) were further examined for their c-Met kinase activity; the compounds showed high efficacy with IC 50 values in the single-digit nM range. An analysis of structure-activity relationships indicated that an unsubstituted or a halogen-substituted phenyl ring on the 2-arylquinoline-4-carboxamide moiety was favourable for antitumour activity.