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General Description

2-(1,3-benzodioxol-5-yl)quinoline-4-carbonyl chloride is a chemical compound with the molecular formula C18H20ClNO3. It is a quinoline derivative that contains a benzodioxol ring system and a carbonyl chloride functional group. 2-(1,3-benzodioxol-5-yl)quinoline-4-carbonyl chloride is often used in organic synthesis and pharmaceutical research as a key building block for creating various pharmaceutical drugs and agrochemicals. Its unique structure and functional groups make it an important intermediate in the production of diverse organic compounds. The carbonyl chloride group allows for the compound to act as a reactive intermediate in various chemical reactions, making it a valuable tool in the field of synthetic chemistry.

Upstream product

• 3162-29-6 1-(benzo[d][1,3]dioxol-6-yl)ethanone 
• 174636-86-3 2-(2H-1,3-benzodioxol-5-yl)quinoline-4-carboxylic acid 
• 91-56-5 indole-2,3-dione 
• 42366-35-8 hydroxyimino-N-phenylacetamide 
• 62-53-3 aniline 

Relevant academic research and scientific papers

Discovery of Potent Small-Molecule SIRT6 Activators: Structure-Activity Relationship and Anti-Pancreatic Ductal Adenocarcinoma Activity

SIRT6 activation is thought to be a promising target for the treatment of many diseases, particularly cancer. Herein, we report the discovery of a series of new small-molecule SIRT6 activators. Structure-activity relationship analyses led to the identific

Design, synthesis and biological evaluation of 2-phenylquinoline-4-carboxamide derivatives as a new class of tubulin polymerization inhibitors

A novel series of 2-phenylquinoline-4-carboxamide derivatives was synthesized, characterized and evaluated for its antiproliferative activity against five cancer cell lines, Hela, SK-OV-3, HCT116, A549 and MDA-MB-468, and a normal human fetal lung fibroblastic cell line, MRC-5. Among them, compound 7b displayed potent cytotoxic activity in vitro against SK-OV-3 and HCT116 cell lines with IC50 values of 0.5 and 0.2 μM, respectively. In general, the antiproliferative activity was correlated with the binding property of the colchicine binding site and inhibitory effect on tubulin polymerization. In addition, immunofluorescence and flow cytometry analysis revealed that selected compounds caused disruption of the mitotic spindle assembly and G2/M phase arrest of the cell cycle, which correlated with proliferation inhibitory activity. Molecular docking analysis demonstrated the interaction of 7b at the colchicine binding site of tubulin. These results indicate these compounds are promising inhibitors of tubulin polymerization for the potent treatment of cancer.