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1160264-95-8

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1160264-95-8 Usage

General Description

2-(4-chlorophenyl)-3-methylquinoline-4-carbonyl chloride, also known as 4-Chloro-3-methylquinoline-2-carbonyl chloride, is a chemical compound with the molecular formula C16H10ClNO and a molecular weight of 275.71 g/mol. It is a carbonyl chloride derivative of quinoline, which is a heterocyclic compound with potential bioactive properties. 2-(4-chlorophenyl)-3-methylquinoline-4-carbonyl chloride is used in the synthesis of pharmaceuticals and agrochemicals, and it may also have applications in research and development. The carbonyl chloride functional group is reactive, allowing the compound to participate in a variety of chemical reactions. The presence of the chlorophenyl and methyl groups on the quinoline ring may also impart specific biological or chemical properties to the compound. Overall, 2-(4-chlorophenyl)-3-methylquinoline-4-carbonyl chloride is a versatile chemical with potential applications in various fields.

Check Digit Verification of cas no

The CAS Registry Mumber 1160264-95-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,6,0,2,6 and 4 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1160264-95:
(9*1)+(8*1)+(7*6)+(6*0)+(5*2)+(4*6)+(3*4)+(2*9)+(1*5)=128
128 % 10 = 8
So 1160264-95-8 is a valid CAS Registry Number.

1160264-95-8Downstream Products

1160264-95-8Relevant articles and documents

Discovery of GSK2193874: An Orally Active, Potent, and Selective Blocker of Transient Receptor Potential Vanilloid 4

Cheung, Mui,Bao, Weike,Behm, David J.,Brooks, Carl A.,Bury, Michael J.,Dowdell, Sarah E.,Eidam, Hilary S.,Fox, Ryan M.,Goodman, Krista B.,Holt, Dennis A.,Lee, Dennis,Roethke, Theresa J.,Willette, Robert N.,Xu, Xiaoping,Ye, Guosen,Thorneloe, Kevin S.

, p. 549 - 554 (2017/05/19)

Transient Receptor Potential Vanilloid 4 (TRPV4) is a member of the Transient Receptor Potential (TRP) superfamily of cation channels. TRPV4 is expressed in the vascular endothelium in the lung and regulates the integrity of the alveolar septal barrier. Increased pulmonary vascular pressure evokes TRPV4-dependent pulmonary edema, and therefore, inhibition of TRPV4 represents a novel approach for the treatment of pulmonary edema associated with conditions such as congestive heart failure. Herein we report the discovery of an orally active, potent, and selective TRPV4 blocker, 3-(1,4′-bipiperidin-1′-ylmethyl)-7-bromo-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide (GSK2193874, 28) after addressing an unexpected off-target cardiovascular liability observed from in vivo studies. GSK2193874 is a selective tool for elucidating TRPV4 biology both in vitro and in vivo.

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