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1160264-96-9

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1160264-96-9 Usage

Structure

A carbonyl chloride derivative of quinoline with a chlorine-substituted phenyl group

Usage

Serves as an intermediate in organic synthesis and pharmaceutical research for the synthesis of various pharmaceuticals, dyes, and other organic compounds

Reactivity

Reactive and potentially hazardous chemical

Handling

Should be handled with care

Check Digit Verification of cas no

The CAS Registry Mumber 1160264-96-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,6,0,2,6 and 4 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1160264-96:
(9*1)+(8*1)+(7*6)+(6*0)+(5*2)+(4*6)+(3*4)+(2*9)+(1*6)=129
129 % 10 = 9
So 1160264-96-9 is a valid CAS Registry Number.

1160264-96-9Relevant articles and documents

Discovery of GSK2193874: An Orally Active, Potent, and Selective Blocker of Transient Receptor Potential Vanilloid 4

Cheung, Mui,Bao, Weike,Behm, David J.,Brooks, Carl A.,Bury, Michael J.,Dowdell, Sarah E.,Eidam, Hilary S.,Fox, Ryan M.,Goodman, Krista B.,Holt, Dennis A.,Lee, Dennis,Roethke, Theresa J.,Willette, Robert N.,Xu, Xiaoping,Ye, Guosen,Thorneloe, Kevin S.

, p. 549 - 554 (2017/05/19)

Transient Receptor Potential Vanilloid 4 (TRPV4) is a member of the Transient Receptor Potential (TRP) superfamily of cation channels. TRPV4 is expressed in the vascular endothelium in the lung and regulates the integrity of the alveolar septal barrier. Increased pulmonary vascular pressure evokes TRPV4-dependent pulmonary edema, and therefore, inhibition of TRPV4 represents a novel approach for the treatment of pulmonary edema associated with conditions such as congestive heart failure. Herein we report the discovery of an orally active, potent, and selective TRPV4 blocker, 3-(1,4′-bipiperidin-1′-ylmethyl)-7-bromo-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide (GSK2193874, 28) after addressing an unexpected off-target cardiovascular liability observed from in vivo studies. GSK2193874 is a selective tool for elucidating TRPV4 biology both in vitro and in vivo.

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