1160360-01-9

Upstream product

• 923033-03-8 5-(1-bromoethyl)-1,2,3-trifluorobenzene 
• 137628-16-1 3-bromo-5-chloro-1H-2-pyridone 

Downstream Products

• 1160358-90-6 (R)-5-chloro-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-7-(1-(3,4,5-trifluorophenyl)ethyl)-7H-pyrazolo[3,4-b]pyridine 
• 1160358-91-7 (S)-5-chloro-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-7-(1-(3,4,5-trifluorophenyl)ethyl)-7H-pyrazolo[3,4-b]pyridine 

Relevant academic research and scientific papers

Discovery of a potent pyrazolopyridine series of γ-secretase modulators

The synthesis and structure-activity relationship of a novel series of pyrazolopyridines are reported. These compounds represent a new class of γ-secretase modulators that demonstrate good in vitro potency in inhibiting Aβ42 production. Example

GAMMA SECRETASE MODULATORS

This invention provides novel compounds that are modulators of gamma secretase. The compounds have the formula (I) wherein R2 is a fused bicyclic ring of the formula (II). Also disclosed are methods of modulating gamma secretase activity and methods of treating Alzheimer's disease using the compounds of formula (I).