1160360-19-9Relevant academic research and scientific papers
Discovery of fused 5,6-bicyclic heterocycles as γ-secretase modulators
Qin, Jun,Dhondi, Pawan,Huang, Xianhai,Mandal, Mihirbaran,Zhao, Zhiqiang,Pissarnitski, Dmitri,Zhou, Wei,Aslanian, Robert,Zhu, Zhaoning,Greenlee, William,Clader, John,Zhang, Lili,Cohen-Williams, Mary,Jones, Nicholas,Hyde, Lynn,Palani, Anandan
, p. 664 - 669 (2011)
We herein report the discovery of four series of fused 5,6-bicyclic heterocycles as γ-secretase modulators. Synthesis and SAR of these series are discussed. These compounds represent a new class of γ-secretase modulators that demonstrate moderate to good
GAMMA SECRETASE MODULATORS
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Page/Page column 214, (2009/07/17)
This invention provides novel compounds that are modulators of gamma secretase. The compounds have the formula (I) wherein R2 is a fused bicyclic ring of the formula (II). Also disclosed are methods of modulating gamma secretase activity and methods of treating Alzheimer's disease using the compounds of formula (I).
