1160431-71-9

Upstream product

• 1160431-42-4 ethyl 1-(6-(3,5-difluoro-2-hydroxyphenyl)pyridin-2-yl)piperidine-4-carboxylate 
• 156001-49-9 4-bromo-2-methylbenzyl bromide 

Downstream Products

• 1160430-32-9 1-[6-(3,5-difluoro-2-(2-methyl-4-(4-trifluoromethylphenyl)benzyloxy)-phenyl)pyridin-2-yl]-piperidine-4-carboxylic acid 

Relevant academic research and scientific papers

NOVEL SOLUBLE GUANYLATE CYCLASE ACTIVATORS AND THEIR USE

The invention relates to activators of soluble guanylate cyclase of generic formula (I) and their use in pharmaceutical compositions, primarily topically administered ophthalmic compositions. The pharmaceutical compositions are useful for reducing intraocular pressure in animals of the mammalian species.

2,6-DISUBSTITUTED PYRIDINES AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS

Disclosed are compounds of formula (I) wherein R1 and R2 are independently selected from hydrogen, halo, CF3, C1-4alkyl and allyl; Y represents (II), (III), (IV) or (V) wherein R3 represents CF3 or C1-4alkyl; and R3a represents CF3 or C1-4alkyl.