1160436-72-5Relevant academic research and scientific papers
2-(Benzoylimino)thiazolidin-4-ones: Formation by an alternative ring closure and analysis of rotational barriers
Hcker, Hans-Georg,Elsinghorst, Paul W.,Michels, Susanne,Daniels, Joerg,Schnakenburg, Gregor,Guetschow, Michael
experimental part, p. 1195 - 1203 (2009/12/04)
The reactions of N-benzoyl-N'-(o-cyanoaryl)thioureas with ethyl bromoacetate under alkaline conditions led to the formation of either fused 2-(alkylsulfanyl)-4-aminopyrimidines or 2-(benzoylimino)-3-(o-cyanoaryl) thiazolidin-4-ones. The accurate applicati
Analogs of a 4-aminothieno[2,3-d]pyrimidine lead (QB13) as modulators of P-glycoprotein substrate specificity
Haecker, Hans-Georg,Haye, Antje de la,Sterz, Katja,Schnakenburg, Gregor,Wiese, Michael,Guetschow, Michael
supporting information; experimental part, p. 6102 - 6105 (2010/06/19)
P-glycoprotein (P-gp) is an important factor in the development of multidrug resistance (MDR) in cancer cells. In literature reports, a thieno[2,3-d]pyrimidine (QB13) was described as P-gp modulator and opposed effects on the cell accumulation of distinct
