1160502-10-2

Usage

Uses

Used in Organic Synthesis:
2-Methyl-2-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-propionitrile is used as a reagent in organic synthesis for the introduction of boron atoms into organic molecules. Its presence in the molecule allows for a variety of chemical reactions and transformations, making it a valuable building block in the creation of complex organic structures.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 2-Methyl-2-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-propionitrile is utilized as a key intermediate in the preparation of pharmaceuticals. Its unique properties and reactivity contribute to the development of new drugs with improved therapeutic profiles.
Used in the Preparation of Agrochemicals:
2-Methyl-2-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-propionitrile is also employed in the agrochemical industry, where it serves as a precursor for the synthesis of various agrochemicals. Its ability to introduce boron atoms into molecules makes it a useful component in the development of new pesticides and other agricultural products.
Used in the Development of Materials:
2-Methyl-2-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-propionitrile is further utilized in the materials industry, where its unique chemical properties are harnessed to create new materials with specific characteristics. The incorporation of boron atoms can enhance the properties of these materials, making them suitable for various applications.

Upstream product

• 90433-20-8 2-(3-bromo-phenyl)-2-methyl-propionitrile 
• 73183-34-3 bis(pinacol)diborane 

Downstream Products

• 1160498-05-4 2-(3-(1H-pyrazolo[3,4-b]pyridin-4-yl)phenyl)-2-methylpropanenitrile 
• 1160500-88-8 2-methyl-2-(3-(5-methyl-1H-pyrazolo[3,4-b]pyridin-4-yl)phenyl)propanenitrile 
• 1160498-59-8 2-(3-(1H-pyrazolo[3,4-b]pyridin-4-yl)phenyl)-2-methylpropan-1-amine 

Relevant academic research and scientific papers

Discovery of selective, orally bioavailable pyrazolopyridine inhibitors of protein kinase cθ (pkcθ) that ameliorate symptoms of experimental autoimmune encephalomyelitis

PKCθ plays an important role in T cell biology and is a validated target for a number of disease states. A series of potent and selective PKCθ inhibitors were designed and synthesized starting from a HTS hit compound. Cell activity, while initially a challenge to achieve, was built into the series by transforming the nitrile unit of the scaffold into a primary amine, the latter predicted to form a new hydrogen bond to Asp508 near the entrance of the ATP binding site of PKCθ. Significant improvements in physiochemical parameters were observed on introduction of an oxetane group proximal to a primary amine leading to compound 22, which demonstrated a reduction of symptoms in a mouse model of multiple sclerosis.

[1H- PYRAZOLO [3, 4-B] PYRIDINE-4-YL] -PHENYLE OR -PYRIDIN-2-YLE DERIVATIVES AS PROTEIN KINASE C-THETA

The present invention relates to compounds of formula (I) and (IA) useful as inhibitors of protein kinase (1a). The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions. (a) : in particular protein kinase C theta, wherein A and A' are independently -N- or -C(R+) -. Ring B is five- or six-membered saturated carbocyclic or heterocyclic R1, R2, R3, R4, R5, R6, R7, x and y are as described herein.