1160616-35-2

Upstream product

• 1160616-67-0 4,5-dimethoxy-2-(methoxymethoxymethyl)benzonitrile 
• 2728-04-3 N,N-diethyl-ortho-toluamide 

Downstream Products

• 1160616-48-7 C₁₈H₁₇NO₄ 
• 1338475-35-6 2-allyl-3-(2-hydroxymethyl-4,5-dimethoxyphenyl)-2H-isoquinolin-1-one 
• 1338475-39-0 2-(2-allyl-1-oxo-1,2-dihydroisoquinolin-3-yl)-4,5-dimethoxybenzaldehyde 
• 1338475-43-6 2-allyl-3-(4,5-dimethoxy-2-vinylphenyl)-2H-isoquinolin-1-one 
• 1338475-31-2 2-allyl-3-(4,5-dimethoxy-2-(methoxymethoxymethyl)phenyl)-2H-isoquinolin-1-one 

Relevant academic research and scientific papers

Synthesis of benzo[3,4]azepino[1,2-b]isoquinolin-9-ones from 3-arylisoquinolines via ring closing metathesis and evaluation of topoisomerase i inhibitory activity, cytotoxicity and docking study

Benzo[3,4]azepino[1,2-b]isoquinolinones were designed and developed as constraint forms of 3-arylisquinolines with an aim to inhibit topoisomerase I (topo I). Ring closing metathesis (RCM) of 3-arylisoquinolines with suitable diene moiety provided seven m

Structural modification of 3-arylisoquinolines to isoindolo[2,1-b]isoquinolinones for the development of novel topoisomerase 1 inhibitors with molecular docking study

Isoindolo[2,1-b]isoquinolinones 9a-i were designed and synthesized as constrained forms of 3-arylisoquinolines through an intramolecular cyclization reaction. Among the synthesized compounds, 9d exhibited potent topoisomerase 1 inhibitory activity with cy