116063-84-4Relevant academic research and scientific papers
Design and synthesis of a novel series of cyanoindole derivatives as potent γ-secretase modulators
Bischoff, Fran?ois P.,Velter, Adriana Ingrid,Minne, Garrett,Pieters, Serge,Berthelot, Didier,De Cleyn, Michel,Gijsen, Harrie J.M.,Macdonald, Gregor,Surkyn, Michel,Van Brandt, Sven,Van Roosbroeck, Yves,Zavattaro, Chiara,Mercken, Marc,Austin, Nigel,Dhuyvetter, Deborah,Borghys, Herman,Ahmad, Ishtiyaque,Samanta, Swapan Kumar
, p. 1737 - 1745 (2019/05/22)
The discovery, design and synthesis of a new series of GSMs is described. The classical imidazole heterocycle has been replaced by a cyano group attached to an indole nucleus. The exploration of this series has led to compound 26-S which combined high in
o-Trifluoromethyl benzaldehyde-chromium-tricarbonyl; a new chiral complex: synthesis, resolution and perfluoroalkylation.
Solladie-Cavallo, A.,Farkhani, D.,Dreyfuss, A. C.,Sanch, F.
, p. 906 - 909 (2007/10/02)
The chromium-tricarbonyl complex of o-trifluoromethyl benzaldehyde is synthesized and resolved in excellent yields.The IR absolute configuration is proposed for the (-) complex.Nucleophilic addition of perfluoroalkyllithium occurs with 95 percent yield an
