1160636-00-9Relevant articles and documents
A new synthesis of alkene-containing minor-groove binders and essential hydrogen bonding in binding to DNA and in antibacterial activity
Anthony, Nahoum G.,Breen, David,Donoghue, Gavin,Khalaf, Abedawn I.,MacKay, Simon P.,Parkinson, John A.,Suckling, Colin J.
experimental part, p. 1843 - 1850 (2009/06/27)
A practical synthesis of alkene-containing minor-groove binders for DNA, related to distamycin, with potential for wide structural diversity is described, based upon the Wittig chemistry of N-alkylpyrrole aldehydes. The compounds prepared have been evalua