116071-72-8

Basic information

• Product Name: (4'-fluoro[1,1'-biphenyl]-4-yl)(4-fluorophenyl)methanone
• Synonyms: (4'-fluoro[1,1'-biphenyl]-4-yl)(4-fluorophenyl)methanone
• CAS NO: 116071-72-8
• Molecular Formula: C19H12F2O
• Molecular Weight: 294.2947864
• Mol File: 116071-72-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (4'-fluoro[1,1'-biphenyl]-4-yl)(4-fluorophenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (4'-fluoro[1,1'-biphenyl]-4-yl)(4-fluorophenyl)methanone(116071-72-8)
• EPA Substance Registry System: (4'-fluoro[1,1'-biphenyl]-4-yl)(4-fluorophenyl)methanone(116071-72-8)

Safety Data

• Hazardous Substances Data: 116071-72-8(Hazardous Substances Data)

Upstream product

• 1765-93-1 4-fluoroboronic acid 

Relevant articles and documents

A synthesis of biaryl ketones via the C–S bond cleavage of thiol ester by a Cu/Ag salt

We report the synthesis of biaryl ketones via an unprecedented copper/silver catalyzed acylative cross-coupling of thiol esters with either an arylboronic acid or a potassium aryltrifluoroborate. This new method proceeds without a requisite Pd-catalyst and Cu(I)TC mediator, and is efficient, versatile, operationally simple, and accommodating functionally diverse thiol esters, arylboronic acids, and potassium aryltrifluoroborates.

Preparation of aryl carbonyl compounds

Friedel Crafts preparation of aryl carbonyl compounds having an exceptionally high degree of isomeric purity and freedom from by-products can be achieved by adding to the Lewis acid reaction system a protic controlling agent selected from ROX, water, RCOOX, RSO3 X, and ROY, wherein R is organic, X is hydrogen or metal, and Y is metal. Contrary to conventional expectation, the protic agent does not significantly alkylate or acylate the Friedel Crafts reaction product.