1160720-78-4

Basic information

• Product Name: (5-bromo-thiophen-3-yl)-(3,3-dimethyl-piperidin-1-yl)-methanone
• Synonyms: (5-bromo-thiophen-3-yl)-(3,3-dimethyl-piperidin-1-yl)-methanone
• CAS NO: 1160720-78-4
• Molecular Weight: 302.235
• Mol File: 1160720-78-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (5-bromo-thiophen-3-yl)-(3,3-dimethyl-piperidin-1-yl)-methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (5-bromo-thiophen-3-yl)-(3,3-dimethyl-piperidin-1-yl)-methanone(1160720-78-4)
• EPA Substance Registry System: (5-bromo-thiophen-3-yl)-(3,3-dimethyl-piperidin-1-yl)-methanone(1160720-78-4)

Safety Data

• Hazardous Substances Data: 1160720-78-4(Hazardous Substances Data)

Upstream product

• 1193-12-0 3,3-dimethylpiperidine 
• 100523-84-0 2-bromothiophene-4-carboxylic acid 

Relevant articles and documents

AMIDO-THIOPHENE COMPOUNDS AND THEIR USE AS 11-BETA-HSD1 INHIBITORS

The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain amido-thiophene compounds that, inter alia, inhibit 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit 11β-hydroxysteroid dehydrogenase type 1; to treat disorders that are ameliorated by the inhibition of 11β-hydroxysteroid dehydrogenase type 1; to treat the metabolic syndrome, which includes disorders such as type 2 diabetes and obesity, and associated disorders including insulin resistance, hypertension, lipid disorders and cardiovascular disorders such as ischaemic (coronary) heart disease; to treat CNS disorders such as mild cognitive impairment and early dementia, including Alzheimer's disease; etc. Formula (I).