1160720-95-5

Upstream product

• 1160720-58-0 4-(4-carboxy-thiophen-2-yl)-piperidine-1-carboxylic acid tert-butyl ester 
• 3466-80-6 2-phenylpiperidine 

Downstream Products

• 1160718-81-9 (2-phenyl-piperidin-1-yl)-(5-piperidin-4-yl-thiophen-3-yl)methanone 

Relevant academic research and scientific papers

AMIDO-THIOPHENE COMPOUNDS AND THEIR USE AS 11-BETA-HSD1 INHIBITORS

The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain amido-thiophene compounds that, inter alia, inhibit 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit 11β-hydroxysteroid dehydrogenase type 1; to treat disorders that are ameliorated by the inhibition of 11β-hydroxysteroid dehydrogenase type 1; to treat the metabolic syndrome, which includes disorders such as type 2 diabetes and obesity, and associated disorders including insulin resistance, hypertension, lipid disorders and cardiovascular disorders such as ischaemic (coronary) heart disease; to treat CNS disorders such as mild cognitive impairment and early dementia, including Alzheimer's disease; etc. Formula (I).