1160723-45-4

Basic information

• Product Name: N-(4-tolylethynyl)-N-methanesulfonylbenzylamine
• Synonyms: N-(4-tolylethynyl)-N-methanesulfonylbenzylamine
• CAS NO: 1160723-45-4
• Molecular Weight: 299.393
• Mol File: 1160723-45-4.mol

Chemical Properties

• CAS DataBase Reference: N-(4-tolylethynyl)-N-methanesulfonylbenzylamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-tolylethynyl)-N-methanesulfonylbenzylamine(1160723-45-4)
• EPA Substance Registry System: N-(4-tolylethynyl)-N-methanesulfonylbenzylamine(1160723-45-4)

Safety Data

• Hazardous Substances Data: 1160723-45-4(Hazardous Substances Data)

Upstream product

• 33491-05-3 1-(2-bromoethynyl)-4-methylbenzene 
• 3989-45-5 N-benzylmethanesulfonamide 

Relevant articles and documents

Zinc-Catalyzed Alkyne Oxidation/C-H Functionalization: Highly Site-Selective Synthesis of Versatile Isoquinolones and β-Carbolines

An efficient zinc(II)-catalyzed alkyne oxidation/C￡H functionalization sequence was developed, thus leading to highly site-selective synthesis of a variety of isoquinolones and β-carbolines. Importantly, in contrast to the well-established gold-catalyzed intermolecular alkyne oxidation, over-oxidation can be completely suppressed in this system and the reaction most likely proceeds by a Friedel-Crafts-type pathway. Mechanistic studies and theoretical calculations are described.

Facile one-pot synthesis of 2-aminoindoles from simple anilines and ynamides

A highly effective and straightforward one-pot synthesis of diversely substituted 2-aminoindoles has been developed, involving sequential Au(i)-catalyzed regioselective hydroamination and CuCl2-mediated oxidative cyclization. This protocol offers an operationally easy, simple, robust, and sustainable approach with the use of readily available starting materials, good functional group tolerance, and high practicality and efficiency. This journal is

Synthesis of 2-Aza-1,3-butadienes through Gold-Catalyzed Intermolecular Ynamide Amination/C-H Functionalization

A novel gold-catalyzed tandem intermolecular ynamide amination/C-H functionalization has been developed. A variety of highly functionalized 2-aza-1,3-butadienes can be obtained readily by utilizing this strategy. In addition, α-imino gold carbene intermediates are proposed in this amination reaction and with support by DFT (density functional theory) calculations.

Iron-catalyzed amidation of alkynyl bromides: A facile route for the preparation of ynamides

(Chemical Equation Presented) A facile route to obtain ynamides in high yields was described. The products were achieved through the iron-catalyzed C-N coupling reaction of amides with alkynyl bromides in the presence of 20 mol % of N,N′-dimethylethane-1,2-diamine (DMEDA).