116078-61-6Relevant articles and documents
Process for the preparation of heterocyclic alkylamide derivatives
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, (2008/06/13)
The present invention relates to a novel process for the preparation of N-heterocyclealkanamide derivatives having the following formula: STR1 which comprises reacting 1-(2-chloroethyl)piperidine with 2-chlorobenzeneacetonitrile to give (±)-α-(2-chlorophe
Synthesis and structure-activity relationships of a new series of antiarrhythmic agents: Monobasic derivatives of disobutamide
Desai,Fowler,Chorvat,Frederick,Hatley,Rorig,Garthwaite
, p. 2158 - 2164 (2007/10/02)
Analogues of the dibasic antiarrhythmic agent disobutamide (2) were prepared and evaluated for antiarrhythmic efficacy, myocardial depression, and anticholinergic activity. The replacement of an isopropyl group in disobutamide by an acetyl group led to the monoclasic analogue SC-40230, 7a, which demonstrated good antiarrhythmic activity accompanied by less myocardial depressant and anticholinergic activities. In addition, it did not induce clear cytoplasmic vacuoles as did the parent compound. SC-40230 was chosen from among other analogues as a candidate for clinical evaluation. Other compounds prepared and evaluated included indolizidinones and a secondary amine isomer of disobutamide.