1160829-10-6Relevant articles and documents
Synthesis and biological evaluation of ((4-keto)-phenoxy)methyl biphenyl-4-sulfonamides: A class of potent aggrecanase-1 inhibitors
Hopper, Darrin W.,Vera, Matthew D.,How, David,Sabatini, Joshua,Xiang, Jason S.,Ipek, Manus,Thomason, Jennifer,Hu, Yonghan,Feyfant, Eric,Wang, Qin,Georgiadis, Katy E.,Reifenberg, Erica,Sheldon, Richard T.,Keohan, Cristin C.,Majumdar, Manas K.,Morris, Elisabeth A.,Skotnicki, Jerauld,Sum, Phaik-Eng
scheme or table, p. 2487 - 2491 (2009/12/25)
The prevention of aggrecan (a key component of cartilage) cleavage via the inhibition of aggrecanase-1 may provide a unique opportunity to stop the progression of cartilage degradation in osteoarthritis. The evaluation of a series of biphenylsulfonamides