1160844-45-0Relevant academic research and scientific papers
Integrin-targeted nano-sized polymeric systems for paclitaxel conjugation: a comparative study
Eldar-Boock, Anat,Blau, Rachel,Ryppa, Claudia,Baabur-Cohen, Hemda,Many, Ariel,Vicent, María Jesús,Kratz, Felix,Sanchis, Joaquin,Satchi-Fainaro, Ronit
, p. 829 - 844 (2017/10/06)
The generation of rationally designed polymer therapeutics via the conjugation of low molecular weight anti-cancer drugs to water-soluble polymeric nanocarriers aims to improve the therapeutic index. Here, we focus on applying polymer therapeutics to targ
POLYMERIC SYSTEMS AND USES THEREOF IN THERANOSTIC APPLICATIONS
-
Page/Page column 85; 86, (2015/10/05)
Polymeric systems useful for theranostic applications are disclosed. The polymeric systems comprise a fluorescent or fluorogenic moiety and a therapeutically active agent, each attached to the same or different polymeric moiety. The polymeric systems are designed such that a fluorescent signal is generated in response to a chemical event, preferably upon contacting an analyte (e.g., an enzyme) that is over- expressed in a diseased tissue or organ. Probes useful for inclusion in such polymeric systems, processes of preparing such probes and the polymeric systems, and uses thereof in diagnostic and/or theranostic applications are also disclosed.
CONJUGATES OF A POLYMER, A BISPHOSPHONATE AND AN ANTI-ANGIOGENESIS AGENT AND USES THEREOF IN THE TREATMENT AND MONITORING OF BONE RELATED DISEASES
-
Paragraph 0407; 0408, (2016/01/26)
Conjugates of polymers or copolymers having attached thereto an anti-angiogenesis agent and a bisphosphonate bone targeting agent, and processes of preparing same, are disclosed. Pharmaceutical compositions containing these conjugates and uses thereof in
Enhanced cytotoxicity of a polymer-drug conjugate with triple payload of paclitaxel
Erez, Rotem,Segal, Ehud,Miller, Keren,Satchi-Fainaro, Ronit,Shabat, Doron
experimental part, p. 4327 - 4335 (2009/11/30)
The development of targeting approaches to selectively release chemotherapeutic drugs into malignant tissue is a major challenge in anticancer therapy. We have synthesized an N-(2-hydroxypropyl)-methacrylamide (HPMA) copolymer-drug conjugate with an ABsu
