1160861-59-5

Basic information

• Product Name: 2-(Di-1-adaMantylphosphino)-3,6-diMethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl, Min. 95% AdBrettPhos
• Synonyms: Di-Ad-BrettPhos;AdBrettPhos 95%;2-(Di-1-adaMantylphosphino)-3,6-diMethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl, Min. 95% AdBrettPhos;2-(Di-1-adaMantylphosphino)-3,6-diMethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl;AdBrettPhos;2-(Di-1-adamantylphosphino)-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl,AdBrettPhos
• CAS NO: 1160861-59-5
• Molecular Formula: C₄₃H₆₁O₂P
• Molecular Weight: 640.917001
• Product Categories: Buchwald Ligands Series;Achiral Phosphine;Aryl Phosphine;Buchwald Ligands&Precatalysts
• Mol File: 1160861-59-5.mol
• Article Data: 1

Chemical Properties

• Melting Point: 231-235°C
• Appearance: off-white to pale yellow/Powder
• CAS DataBase Reference: 2-(Di-1-adaMantylphosphino)-3,6-diMethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl, Min. 95% AdBrettPhos(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(Di-1-adaMantylphosphino)-3,6-diMethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl, Min. 95% AdBrettPhos(1160861-59-5)
• EPA Substance Registry System: 2-(Di-1-adaMantylphosphino)-3,6-diMethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl, Min. 95% AdBrettPhos(1160861-59-5)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 1160861-59-5(Hazardous Substances Data)

Usage

Reaction

Ligand used in the palladium-catalyzed amidation of five-membered heterocycles as electrophiles.

Upstream product

• 1070663-76-1 2-iodo-2’,4’,6’-triisopropyl-3,6-dimethoxybiphenyl 
• 157282-19-4 di-1-adamantylchlorophosphane 
• 768-90-1 1-Adamantyl bromide 

Downstream Products

• 1380328-46-0 BrPd(C₆H₄CN)(P(C₁₀H₁₅)2C₆H₂(OCH₃)2C₆H₂(CH(CH₃)2)3) 

Relevant articles and documents

A bulky biaryl phosphine ligand allows for palladium-catalyzed amidation of five-membered heterocycles as electrophiles

The incredible bulk: The first palladium-catalyzed amidation of five-membered heterocyclic bromides with multiple heteroatoms was achieved using the Pd/1 catalyst system. N-Arylated imidazoles, pyrazoles, thiazoles, pyrroles, and thiophenes were synthesized in moderate to excellent yield. Experimental results and DFT calculations point to the need for an electron-rich and sterically demanding biaryl phosphine ligand to promote these difficult reactions. Copyright