116089-38-4Relevant articles and documents
Uebergangsmetallkomplexe mit Schwefelliganden XXXIV. II(CO)2>-Fragmente als Templatzentren und Schutzgruppen: Synthese makrozyklischer Thioether und Monoalkylierung von Dithiolen; Roentgenstrukturanalyse von Dibenzo-18-krone-S6, einem planar
Sellmann, Dieter,Frank, Peter,Knoch, Falk
, p. 345 - 356 (1988)
Using metal carbonyl fragments as templates, the directed, bridging alkylation of ligating dithiolates yields macrocyclic polythioethers.Treatment of cis-2- (1) with S(C2H4Br)2, in THF at room temperature, gives Fe(CO)-(dptt
Method of treatment for benign prostatic hyperplasia
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, (2008/06/13)
Disclosed is an improved treatment for men with benign prostatic hyperplasia (BPH), involving combination therapy of a 5α-reductase inhibitor, e.g. a 17β-substituted 4-azasteroid, a 17β-substituted non-azasteroid, 17β-acyl-3-carboxy-androst-3,5-diene, benzoylaminophenoxybutanoic acid derivative, fused benz(thio)amide or cinnamoylamide derivative, aromatic 1,2-diethers or thioethers, aromatic ortho acylaminophenoxy alkanoic acids, ortho thioalkylacylaminophenoxy alkanoic acids, pharmaceutically acceptable salts and esters thereof, and particularly finasteride, in combination with an α1 -adrenergic receptor blocker, i.e., terazosin. The combination provides therapy at the molecular level for the underlying cause of the disease as well as providing symptomatic relief. Pharmaceutical compositions useful for treatment are also disclosed.
