1160913-71-2

Basic information

• Product Name: (E)-N-(4-methoxyphenyl)-6-methyl-2-oxo-4-styryl-1,2,3,4-tetrahydropyrimidine-5-carboxamide
• CAS NO: 1160913-71-2
• Molecular Weight: 363.416
• Mol File: 1160913-71-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-N-(4-methoxyphenyl)-6-methyl-2-oxo-4-styryl-1,2,3,4-tetrahydropyrimidine-5-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-N-(4-methoxyphenyl)-6-methyl-2-oxo-4-styryl-1,2,3,4-tetrahydropyrimidine-5-carboxamide(1160913-71-2)
• EPA Substance Registry System: (E)-N-(4-methoxyphenyl)-6-methyl-2-oxo-4-styryl-1,2,3,4-tetrahydropyrimidine-5-carboxamide(1160913-71-2)

Safety Data

• Hazardous Substances Data: 1160913-71-2(Hazardous Substances Data)

Upstream product

• 14371-10-9 (E)-3-phenylpropenal 
• 5437-98-9 4'-methoxyacetoacetanilide 
• 57-13-6 urea 

Relevant articles and documents

Synthesis of novel Hantzsch dihydropyridines and Biginelli dihydropyrimidines of biological interest: A 3D-QSAR study on their cytotoxicity

We report a library consisting of some novel Hantzsch dihydropyridines and Biginelli dihydropyrimidines of biological interest as well as their synthesis and analysis. The important steps in the synthetic part were found to be Hantzsch and Biginelli multicomponent reactions. The synthesized compounds were screened for their in vitro antibacterial activity against two gram-positive bacteria: Staphylococcus aureus and Bacillus subtilis. The title compounds did not exhibit potential antibacterial activity. Furthermore, compounds were subjected to in vitro cytotoxicity against Vero cells. Compounds exhibited weak, moderate, or high cytotoxicity. Compounds 4a, 4b, 4c, 4f, 4g, 4h, 4i, 7i, 7l, 7m, and 7r exhibited potential cytotoxicity. CoMFA study has resulted in the identification of structural features contributing toward their cytotoxicity.