1160936-96-8Relevant articles and documents
High-Pressure Accelerated Enantioselective Addition of Indoles to Trifluoromethyl Ketones with a Low Loading of Chiral BINOL-Derived Phosphoric Acid
Biedrzycki, Micha?,Kasztelan, Adrian,Kwiatkowski, Piotr
, p. 2453 - 2456 (2017)
The effect of pressure (up to 10 kbar) on the Br?nsted acid catalyzed enantioselective hydroxyalkylation of indoles with trifluoromethyl ketones was explored. The reaction was effectively accelerated at 9 kbar with a very low loading of a 1,1′-bi-2-naphthol (BINOL) -derived phosphoric acid (0.05–0.2 mol % of TRIP) and provided the products with high enantioselectivity (84–98 % ee).
A perfect double role of CF3 groups in activating substrates and stabilizing adducts: The chiral Bronsted acid-catalyzed direct arylation of trifluoromethyl ketones
Nie, Jing,Zhang, Guang-Wu,Wang, Lian,Fu, Aiping,Zheng, Yan,Ma, Jun-An
supporting information; experimental part, p. 2356 - 2358 (2009/09/06)
A direct and efficient Bronsted acid-promoted arylation of tri- and difluoromethyl ketones, as well perfluoroalkyl ketones, has been developed; good to excellent enantioselectivities (up to 99% ee) were achieved. The Royal Society of Chemistry 2009.