1160943-80-5

Basic information

• Product Name: C₂₁H₂₀N₂O₄S
• Synonyms: C₂₁H₂₀N₂O₄S
• CAS NO: 1160943-80-5
• Molecular Weight: 396.467
• Mol File: 1160943-80-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₁H₂₀N₂O₄S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₂₀N₂O₄S(1160943-80-5)
• EPA Substance Registry System: C₂₁H₂₀N₂O₄S(1160943-80-5)

Safety Data

• Hazardous Substances Data: 1160943-80-5(Hazardous Substances Data)

Upstream product

• 31166-44-6 phenylmethyl 1-piperazinecarboxylate 
• 360576-01-8 6-bromo-benzo[b]thiophene-2-carboxylic acid methyl ester 

Relevant articles and documents

BENZOTHIOPHENE DERIVATIVES

The present invention relates to a novel class of benzothiophene amide derivatives. The hydroxamic acid compounds can be used to treat cancer. The benzothiophene amide compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the hydroxamic acid derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the hydroxamic acid derivatives in vivo.