1160994-79-5 Usage
Description
2,4-Dichloro-5-methylfuro[2,3-d]pyrimidine is a chemical compound characterized by its molecular formula C6H3Cl2N3O. It is an organic compound that features a furan ring and a pyrimidine ring, both of which are heterocyclic aromatic rings. 2,4-Dichloro-5-methylfuro[2,3-d]pyrimidine is recognized for its role as a building block in the synthesis of biologically active molecules, particularly in the pharmaceutical and agrochemical industries.
Uses
Used in Pharmaceutical Industry:
2,4-Dichloro-5-methylfuro[2,3-d]pyrimidine is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure and chemical properties make it a valuable component in the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 2,4-Dichloro-5-methylfuro[2,3-d]pyrimidine serves as an intermediate in the production of agrochemicals. Its incorporation into these products can contribute to the development of more effective and targeted pest control solutions.
Used as a Chemical Intermediate:
2,4-Dichloro-5-methylfuro[2,3-d]pyrimidine is also utilized as an intermediate in the production of other important chemicals. Its versatility in chemical reactions allows for its use in a wide range of applications, further expanding its utility in the chemical industry.
Physical Properties:
2,4-Dichloro-5-methylfuro[2,3-d]pyrimidine is a white to off-white crystalline solid, which is indicative of its purity and stability. It has a melting point of around 220-222°C, a characteristic that can be used to assess the quality and consistency of the compound in various applications.
Check Digit Verification of cas no
The CAS Registry Mumber 1160994-79-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,6,0,9,9 and 4 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1160994-79:
(9*1)+(8*1)+(7*6)+(6*0)+(5*9)+(4*9)+(3*4)+(2*7)+(1*9)=175
175 % 10 = 5
So 1160994-79-5 is a valid CAS Registry Number.
1160994-79-5Relevant articles and documents
Discovery of dual orexin receptor antagonists with rat sleep efficacy enabled by expansion of the acetonitrile-assisted/diphosgene-mediated 2,4-dichloropyrimidine synthesis
Roecker, Anthony J.,Mercer, Swati P.,Harrell, C. Meacham,Garson, Susan L.,Fox, Steven V.,Gotter, Anthony L.,Prueksaritanont, Thomayant,Cabalu, Tamara D.,Cui, Donghui,Lemaire, Wei,Winrow, Christopher J.,Renger, John J.,Coleman, Paul J.
, p. 2079 - 2085 (2014/05/06)
Recent clinical studies have demonstrated that dual orexin receptor antagonists (OX1R and OX2R antagonists or DORAs) represent a novel treatment option for insomnia patients. Previously we have disclosed several compounds in the diazepane amide DORA series with excellent potency and both preclinical and clinical sleep efficacy. Additional SAR studies in this series were enabled by the expansion of the acetonitrile-assisted, diphosgene-mediated 2,4-dichloropyrimidine synthesis to novel substrates providing an array of Western heterocycles. These heterocycles were utilized to synthesize analogs in short order with high levels of potency on orexin 1 and orexin 2 receptors as well as in vivo sleep efficacy in the rat.
