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1160995-19-6

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1160995-19-6 Usage

General Description

Tert-Butyl 2-Methyl-5H-pyrrolo[3,4-d]pyrimidin-6(7H)-carboxylate is a specialised chemical compound with complex molecular structure. It belongs to the organic compound class called Pyrrolopyrimidines, which are polycyclic aromatic compounds containing a pyrrolo ring fused to a pyrimidine ring. The function of this compound in various applications is not readily available due to its highly specific nature, and it is used mostly in specialised scientific research or industrial settings. Its exact properties, including toxicity and potential uses, would depend on specific conditions and other compounds it would be used in combination with.

Check Digit Verification of cas no

The CAS Registry Mumber 1160995-19-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,6,0,9,9 and 5 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1160995-19:
(9*1)+(8*1)+(7*6)+(6*0)+(5*9)+(4*9)+(3*5)+(2*1)+(1*9)=166
166 % 10 = 6
So 1160995-19-6 is a valid CAS Registry Number.

1160995-19-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name tert-Butyl 2-methyl-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate

1.2 Other means of identification

Product number -
Other names tert-butyl 2-methyl-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1160995-19-6 SDS

1160995-19-6Downstream Products

1160995-19-6Relevant articles and documents

BICYCLIC INHIBITORS OF HISTONE DEACETYLASE

-

, (2019/02/25)

Provided herein are compounds and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of conditions associated with inhibition of HDAC (e.g,. HDAC2).

Novel Tetrahydropyrido[4,3-d]pyrimidines as Potent Inhibitors of Chaperone Heat Shock Protein 90

Jiang, Fen,Wang, Hui-Jie,Jin, Yu-Hui,Zhang, Qiong,Wang, Zhi-Hui,Jia, Jian-Min,Liu, Fang,Wang, Lei,Bao, Qi-Chao,Li, Dong-Dong,You, Qi-Dong,Xu, Xiao-Li

, p. 10498 - 10519 (2016/12/16)

Heat shock protein 90 (Hsp90) is a potential target for oncology therapeutics. Some inhibitors have shown antitumor effects in clinical trials, spurring the discovery of small molecule Hsp90 inhibitors. Here, we describe the structural optimization studies of a hit compound, tetrahydropyrido[4,3-d]pyrimidine-based Hsp90 inhibitor 15, which exhibits inhibitory activity against Hsp90. A series of analogues were synthesized, and their structure-activity and structure-property relationships were analyzed. These explorations led to the discovery of compound 73, which exhibited potent in vitro activities, good physicochemical properties, favorable ADME properties, and a potent antitumor effect in an HCT116 xenograft model. Furthermore, 73 exhibited no ocular toxicity in a rat retinal damage model, suggesting it is a relatively safe Hsp90 inhibitor. As a promising antitumor agent, 73 was progressed for further preclinical evaluation.

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