1160995-45-8

Basic information

• Product Name: 2,4-dichloro-6-nitropyrrolo[1,2-f][1,2,4]triazine
• Synonyms: 2,4-dichloro-6-nitropyrrolo[1,2-f][1,2,4]triazine;2,4-Dichloro-6-nitropyrrolo[2,1-f][1,2,4]triazine
• CAS NO: 1160995-45-8
• Molecular Formula: C₆H₂Cl₂N₄O₂
• Molecular Weight: 233.01168
• Mol File: 1160995-45-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 2.00
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,4-dichloro-6-nitropyrrolo[1,2-f][1,2,4]triazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-dichloro-6-nitropyrrolo[1,2-f][1,2,4]triazine(1160995-45-8)
• EPA Substance Registry System: 2,4-dichloro-6-nitropyrrolo[1,2-f][1,2,4]triazine(1160995-45-8)

Safety Data

• Hazardous Substances Data: 1160995-45-8(Hazardous Substances Data)

Usage

General Description

2,4-dichloro-6-nitropyrrolo[1,2-f][1,2,4]triazine is a chemical compound with the molecular formula C5HCl2N5O2. It is a yellow crystalline solid that is mainly used in the production of various pharmaceuticals and agrochemicals. 2,4-dichloro-6-nitropyrrolo[1,2-f][1,2,4]triazine is known for its high thermal stability and is often used as an intermediate in the synthesis of other organic compounds. It is also used as a reagent in chemical research and as a building block for the construction of more complex molecules. Additionally, 2,4-dichloro-6-nitropyrrolo[1,2-f][1,2,4]triazine has potential applications in the development of new materials and as a component in the synthesis of dyes and pigments. However, it is important to handle and use this compound with caution due to its potential for toxicity and environmental impact.

Upstream product

• 1263420-13-8 methyl 1-amino-4-nitro-1H-pyrrole-2-carboxylate 
• 13138-74-4 methyl 4-nitropyrrole-2-carboxylate 
• 53391-50-7 2,2,2-trichloro-1-(4-nitro-1H-pyrrol-2-yl)ethan-1-one 
• 35302-72-8 pyrrol-2-yl trichloromethyl ketone 
• 1245644-73-8 6-nitropyrrolo[2,1-f][1,2,4]triazine-2,4(1H,3H)-dione 
• 1204245-52-2 1-amino-4-nitro-1H-pyrrole-2-carboxamide 
• 1204245-51-1 ethyl 1-amino-4-nitro-1H-pyrrole-2-carboxylate 
• 5930-92-7 Ethyl 4-nitropyrrole-2-carboxylate 

Downstream Products

• 1315585-12-6 N-(2-(4-(cyclopropanecarboxamido)phenylthio)-4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-6-yl)-4-methylpiperazine-1-carboxamide 
• 1315585-24-0 N-(4-((6-(3-(piperidin-1-yl)propanamido)-4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)sulfanyl)phenyl)cyclopropanecarboxamide 
• 1315587-55-3 N-(4-(4-(5-methyl-1H-pyrazol-3-ylamino)-6-nitropyrrolo[2,1-f][1,2,4]triazin-2-ylthio)phenyl)cyclopropanecarboxamide 
• 1334320-78-3 C₂₀H₂₀N₈OS 
• 1315587-58-6 N-(4-(6-(2-bromoacetamido)-4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-2-ylthio)phenyl)cyclopropanecarboxamide 
• 1315585-02-4 N-(2-(4-acetamidophenylthio)-4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-6-yl)-2-(piperidin-1-yl)acetamide 
• 1315587-60-0 (R)-N-(4-((6-(2-(2-(hydroxymethyl)pyrrolidin-1-yl)acetamido)-4-((5-methyl-1H-pyrazol-3-yl)amino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)thio)phenyl)cyclopropanecarboxamide 
• 1315587-65-5 N-(4-((4-((5-methyl-1H-pyrazol-3-yl)amino)-6-(2-(pyrrolidin-1-yl)acetamido)pyrrolo[2,1-f][1,2,4]triazin-2-yl)thio)phenyl)cyclopropanecarboxamide 
• 1315587-63-3 N-(4-((4-((5-methyl-1H-pyrazol-3-yl)amino)-6-(2-morpholinoacetamido)pyrrolo[2,1-f][1,2,4]triazin-2-yl)thio)phenyl)cyclopropanecarboxamide 

Relevant articles and documents

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The synthesis and SAR for a novel series of pyrrolotriazines as pan-Aurora kinase inhibitors are described. Optimization of the cyclopropane carboxamide terminus of lead compound 1 resulted in analogs with high cellular activity and improved rat PK profiles. Notably, compound 17l demonstrated tumor growth inhibition in a mouse xenograft model.