1161015-91-3Relevant articles and documents
A new and general method for the synthesis of tripeptide aldehydes based on the multi-component Ugi reaction
Mroczkiewicz, Micha?,Ostaszewski, Ryszard
experimental part, p. 4025 - 4034 (2009/09/30)
Tripeptide aldehydes, such as Z-Leu-Leu-Leu-H (MG-132), are an important class of compounds due to their biological activity. A new, general method for the synthesis of tripeptide aldehydes based on the multi-component Ugi reaction was developed. A careful choice of isocyanides makes it possible to obtain tripeptide precursors whose functionalization led to target structures. This method can be used for the preparation of tripeptide aldehydes with non-natural amino acid side chains.