1161101-35-4

Upstream product

• 3949-36-8 3-acetylcoumarin 
• 104-88-1 4-chlorobenzaldehyde 
• 109-77-3 malononitrile 
• 90-02-8 salicylaldehyde 

Relevant academic research and scientific papers

Facile one-pot, multicomponent synthesis of pyridines under microwave irradiation

A series of 2-amino-6-(2-oxo-2H-chromen-3-yl)-4-pyridine-3-carbo-nitriles were synthesized by the one-pot, multicomponent reaction of 3-acetyl-coumarin, aromatic aldehydes, malononitrile, and ammonium acetate in acetic acid under microwave irradiation. Th

A practical and highly efficient synthesis of densely functionalized nicotinonitrile derivatives catalyzed by zinc oxide-decorated superparamagnetic silica attached to graphene oxide nanocomposite

Zinc oxide-decorated superparamagnetic silica attached to graphene oxide (Fe3O4/SiO2/PTS-GO-ZnO), as a novel nanocomposite, was designed, and its core-shell structure was appropriately characterized by different spectroscopy or microscopy methods and thermal techniques as well as measuring of its porosity and magnetic properties. The catalytic activity of Fe3O4/SiO2/PTS-GO-ZnO, as a reusable heterogeneous catalyst, was investigated for efficient one-pot multi-component synthesis of medicinally important functionalized 2-amino-6-(2-oxo-2H-chromen-3-yl)-4-arylnicotinonitrile derivatives. The significant features of the present procedure are mild reaction conditions, low loading of the catalyst, high to quantitative yields of the desired products, avoiding the use of toxic heavy metals or solvents, simple isolation and purification of the products, and stability as well as reusability of the catalyst after at least six consecutive runs.

Catalytic synthesis of coumarin-linked nicotinonitrile derivatives via a cooperative vinylogous anomeric-based oxidation

Abstract: In the presented study, we developed a new and efficient strategy for the synthesis of coumarin-linked nicotinonitrile derivatives via a cooperative vinylogous anomeric-based oxidation mechanism. Target compounds were prepared through a four com

A novel and reusable ionically tagged nanomagnetic catalyst: Application for the preparation of 2-amino-6-(2-oxo-2H-chromen-3-yl)-4-arylnicotinonitriles via vinylogous anomeric based oxidation

Herein, we report Fe3O4@O2PO2(CH2)2NH3+CF3CO2? as a novel and reusable ionically tagged nanomagnetic catalyst. It was characterized by

Magnetic cellulose/Ag as a novel eco-friendly nanobiocomposite to catalyze synthesis of chromene-linked nicotinonitriles

In this work, design, preparation and performance of magnetic cellulose/Ag nanobiocomposite as a recyclable and highly efficient heterogeneous nanocatalyst is described. Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD) pattern, vibrating sample magnetometer (VSM) curve, field-emission scanning electron microscopy (FE-SEM) image, energy dispersive X-ray (EDX) analysis and thermogravimetric analysis/differential thermal analysis (TGA/DTA) were used for the characterization. Then, its activity was investigated in the synthesis of 2-amino-6-(2-oxo-2H-chromen-3-yl)-4-phenylnicotinonitrile derivatives. The main advantages of the reaction are high yields and short reaction times. The remarkable magnetic property of the nanobiocomposite catalyst provides easy separation from the reaction mixture by an external magnet without considerable loss of its catalytic activity.

Iron(III) phosphate as a green and reusable catalyst for the synthesis of 4,6-disubstituted 2-aminopyridine-3-carbonitriles

Condensation reaction of aryl aldehydes, methyl ketones, malononitrile, and ammonium acetate in the presence of the green and recyclable catalyst FePO4 affords the corresponding 4,6-disubstituted 2-aminopyridine-3-carbonitriles. Some new derivatives of these compounds are synthesized. The catalyst can be also recycled and reused several times.