116121-50-7

Upstream product

• 2327-02-8 3,4-dichlorophenylurea 
• 42163-56-4 3,5,5-trimethyl-4-hydroxythiazolidine-2-thione 
• 132373-16-1 1-(3,4-Dichloro-phenyl)-3-[3,5,5-trimethyl-2-thioxo-thiazolidin-(4Z)-ylidene]-urea 
• 132373-08-1 1-(3,4-Dichloro-phenyl)-3-[3,4,4-trimethyl-2-thioxo-thiazolidin-(5Z)-ylidene]-urea 
• 116121-36-9 C₁₃H₁₅Cl₂N₃O₂S₂ 
• 116121-34-7 C₁₃H₁₅Cl₂N₃O₂S₂ 
• 132408-12-9 4-(3,4-Dichloro-phenyl)-2-(3,5,5-trimethyl-2-thioxo-thiazolidin-4-yl)-[1,2,4]oxadiazolidine-3,5-dione 
• 132373-06-9 4-(3,4-Dichloro-phenyl)-2-(3,4,4-trimethyl-2-thioxo-thiazolidin-5-yl)-[1,2,4]oxadiazolidine-3,5-dione 

Relevant academic research and scientific papers

REACTION OF CARBAMOYL DERIVATIVES OF 4- AND 5-HYDROXYLAMINOTHIAZOLIDINE-2-THIONES AND 4-HYDROXYLAMINOIMIDAZOLIDIN-2-ONE WITH METHYL CHLOROFORMATE. PROPERTIES OF SUBSTITUTED 1,2,4-OXADIAZOLIDINE-3,5-DIONES.

Acylation with methyl chloroformate of N-monocarbamoyl derivatives of 4- and 5-hydroxylaminothiazolidin-2-thione and 4-hydroxylaminoimidazolidin-2-one, depending on their structure and the reaction conditions, leads either to N,O-bisacylhydroxylamines or to their intramolecular cyclization products, the substituted 1,2,4-oxadiazolidine-3,5-diones which, on decarboxylation, may convert into the corresponding 4- and 5-carbamoyliminothiazolidine-2-thiones.

4- AND 5-HYDROXYLAMINOTHIAZOLIDINE-2-THIONES. REARRANGEMENT OF THE CARBAMOYL DERIVATIVES TO 4- AND 5-UREIDOTHIAZOLIDIN-2-ONES

The carbamoylation of 4- and 5-hydroxylaminothiazolidine-2-thiones by methyl and 3,4-dichlorophenyl isocyanates leads to the corresponding hydroxyureas, which rearrange to 4- and 5-ureidothiazolidin-2-ones on heating in the presence of a base.Under these conditions, the hydroxyurea based on 5-hydroxylaminothiazolidin-2-one is converted to 5-ureidooxazolidin-2-one.