116131-35-2

Basic information

• Product Name: 1-Iodo-4,5-dimethoxy-2-methylbenzene
• Synonyms: 1-Iodo-4,5-dimethoxy-2-methylbenzene
• CAS NO: 116131-35-2
• Molecular Weight: 278.09
• Mol File: 116131-35-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1-Iodo-4,5-dimethoxy-2-methylbenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Iodo-4,5-dimethoxy-2-methylbenzene(116131-35-2)
• EPA Substance Registry System: 1-Iodo-4,5-dimethoxy-2-methylbenzene(116131-35-2)

Safety Data

• Hazardous Substances Data: 116131-35-2(Hazardous Substances Data)

Upstream product

• 452-86-8 4-methyl-1,2-dihydroxybenzene 
• 494-99-5 1,2-dimethoxy-4-methylbenzene 

Downstream Products

• 62012-51-5 4,4',5,5'-tetramethoxy-2,2'-dimethyl-1,1'-biphenyl 

Relevant articles and documents

Rapid Access to Azabicyclo[3.3.1]nonanes by a Tandem Diverted Tsuji–Trost Process

A three-step synthesis of the 2-azabicyclo[3.3.1]nonane ring system from simple pyrroles, employing a combined photochemical/palladium-catalysed approach is reported. Substrate scope is broad, allowing the incorporation of a wide range of functionality relevant to medicinal chemistry. Mechanistic studies demonstrate that the process occurs by acid-assisted C?N bond cleavage followed by β-hydride elimination to form a reactive diene, demonstrating that efficient control of what might be considered off-cycle reactions can result in productive tandem catalytic processes. This represents a short and versatile route to the biologically important morphan scaffold.

Two Stereoinduction Events in One C?H Activation Step: A Route towards Terphenyl Ligands with Two Atropisomeric Axes

Herein we disclose the synthesis of original chiral scaffolds—ortho-orientated terphenyls presenting two atropisomeric Ar–Ar axes. These unusual structures were built up by using the C?H activation approach, and remarkably, both chiral axes were controlled with excellent stereoselectivity in a single transformation. During the reaction, not only does atroposelective functionalization of a biaryl precursor occur to establish one stereogenic axis, but an unprecedented atropo-stereoselective C?H arylation also takes place to generate the second stereogenic element. These enantiomerically pure ortho-terphenyls show an original tridimensional structure and thus constitute a unique foundation for building up a library of enantiomerically pure bidentate ligands, such as the new ligands S/N-Biax and diphosphine BiaxPhos.

Multisubstituted 1-hydroxy-9-acridones with anticancer activity

The present invention provides a compound having the structure: STR1 The present invention also provides a method for synthesizing a compound having the above-identified structure as well as the intermediate compounds produced according to that method. The present invention further provides a pharmaceutical composition comprising the above compounds. Lastly, the present invention provides a method of inhibiting growth of tumor cells.